ECEESPE2025 ePoster Presentations Endocrine Related Cancer (100 abstracts)
Association of schmidt syndrome with papillary thyroid carcinoma
Imen Mhiri 1 , Yesmine Elloumi 2 , Fatma Chaltout 1 , Ghada Mani 1 , Mohamed Maaloul 1 , Salma Charfeddine 1 , Issam Jardak 1 , Fatma Hamza 1 & Khalil Chtourou 1
1Habib Bourguiba Univesity Hospital, Nulcear Medicine Department, Sfax, Tunisia; 2Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT1310
Background: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. The occurrence of PTC in patients with Hashimoto’s thyroiditis (HT) has been reported and a debatable explanation of the association was some common dysregulated non-immune-linked genes involved in DNA damage and repair. However, the link between PTC and autoimmune polyglandular syndromes, such as Schmidt syndrome, has been rarely described, making it an intriguing subject for further investigation.
Case report: We report the case of a 47-year-old female with a history of Addison’s disease who presented with a cervical nodule that appeared suspicious on ultrasound. Fine-needle aspiration biopsy confirmed the presence of papillary thyroid carcinoma. Histopathological examination not only validated the diagnosis of differentiated thyroid carcinoma but also revealed lymphocytic thyroiditis. Laboratory investigations showed elevated anti-thyroglobulin antibodies (56 IU/mL; normal <30 IU/mL) and elevated anti-thyroid peroxidase (TPO) antibodies, with undetectable thyroglobulin levels (<0.04 ng/mL) and high TSH levels. The patient underwent total thyroidectomy, followed by radioactive iodine therapy.
Conclusion: This case highlights the rare association between Schmidt syndrome and papillary thyroid carcinoma, emphasizing the need for increased awareness of thyroid malignancies in patients with autoimmune polyglandular syndromes as underlying autoimmune conditions may influence cancer progression and therapeutic strategies.
Volume 110
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2025 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more