Endocrine Abstracts

JOINT2812

Background: Clinical parameters, such as differential white blood cell counts, are linked to metabolic diseases and insulin resistance. However, the closely clinical markers associated with early-onset obesity, particularly genetic obesity, remain undefined. Given the increasing consensus around the necessity of genetic testing for severe early-onset obesity, there’s a need to enhance the efficacy of such tests. This study endeavors to distinguish between hereditary and non-hereditary obesity using clinical indicators. The goal is to offer a foundation for the early diagnosis of hereditary obesity and subsequent genetic screening. Therefore, we conducted this observational study.

Methods: We identified early-onset obesity in children below five years old, defined by a BMI exceeding the 95th percentile. Recommended interventions included hospitalization for comprehensive obesity assessments encompassing physical examinations, biochemical tests, hormone levels, and genetic screenings.

Results: When compared to the negative Whole Exome Sequencing (WES) group, six distinct gene mutations were identified in the positive WES group: BBS1, MC4R, NCOA1, SH2B1, UCP3, and 15q11-13. This group also demonstrated a significant increase in differential white blood cell count, monocytes, serum ALT, AST, and cortisol levels (P <0.05).

Conclusions: By examining disparities in clinical indicators, this research highlights the potential for genetic obesity screening in early-onset cases. Our findings provide valuable insights for the clinical genetic testing of early-onset obesity.

Keywords: Early-onset obesity, genetic detection, gene mutations, monocyte, white blood cell count.

Disclosure of interest: The authors have not any conflict of interest or competing interest to declare.