ECEESPE2025 ePoster Presentations Metabolism, Nutrition and Obesity (164 abstracts)
Does co-administration of lactate to an oral glucose tolerance test lower the glucose response – a randomized controlled cross-over study
Natasa Brkovic Zubanovic 1,2,3 , Jens Voigt 1,2,3 , Ida Marie Modvig 4 , Mette Glavind Bülow Pedersen 1,2,5 , Julie Bondgaard Løhde 1,2,6 , Lars Gormsen 3,7 , Adrian Vella 8 , Jens J. Holst 4,9 , Nikolaj Rittig 2,3,10 & Esben Søndergaard 1,2,5
1Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark; 2Medical/Steno Aarhus Research Laboratory, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 3Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 4Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark; 5Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; 6Department of Biomedicine, Aarhus University, Aarhus, Denmark; 7Department of Nuclear Medicine and PET-centre, Aarhus University Hospital, Aarhus, Denmark; 8Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, United States; 9Novo Nordicsk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; 10Department of Internal Medicine Horsens Regional Hospital, Horsens, Denmark
JOINT2885
Introduction: Fermented dairy products have been associated with a reduced risk of type 2 diabetes, but the mechanisms remain unclear. Oral lactate has previously been shown to increase insulin levels and delay gastric emptying in healthy individuals. This study investigated whether orally administered lactate affects glucose tolerance, insulin secretion, appetite, and gastric emptying in individuals with pre-diabetes during an oral glucose tolerance test (OGTT).
Methods: In a double-blind, randomized crossover design, 12 individuals with pre-diabetes (HbA1c 39–47 mmol/l) were studied twice after an overnight fast using a 75 g glucose solution: 1) with 25 g sodium lactate (LAC) added, and 2) with a placebo (iso-osmotic sodium chloride, CTR) added. Blood samples and appetite questionnaires were collected, and gastric emptying was assessed using the paracetamol absorption test.
Results: Lactate increased plasma lactate concentrations to 2.6 mmol/l compared to 1.5 mmol/l on the placebo day (incremental area under the curve (iAUC), P <0.001). No differences were observed between interventions for glucose iAUC (-53 (95%CI: -189-86) mmol x min/l, P = 0.42). Insulin concentrations were similar, but C-peptide concentrations trended to be higher on the lactate day compared to the placebo day (iAUC: 62 (95% CI: -2–125) nmol x min/l, P = 0.06). No differences were observed between interventions regarding paracetamol absorption or appetite sensations.
Conclusion: Oral lactate did not improve glucose tolerance in individuals with pre-diabetes and had no effect on insulin secretion, appetite, or gastric emptying. This indicates that adding lactate into carbohydrate-rich meals is unlikely to reduce postprandial glucose excursions in individuals with pre-diabetes.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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