Endocrine Abstracts

JOINT1511

Introduction: Chronic kidney disease (CKD) is a major driver of mortality in patients with type 2 diabetes mellitus (t2DM). CKD is estimated to affect 50 % patients with DM. An increasing number of studies find obesity and t2DM a continuous progression of CKD in patients with and the development of cardiovascular complications.

Purpose: To estimate the pro-oxidant and antioxidant system state, to identify the presence of dependence on lipid profiles in patients with CKD and t2DM in obese and non-obese patients. It was observed 79 diabetic individuals with CKD, which were categorized into two groups: obese and non-obese, according to their body mass index (BMI). Group 1 (n = 35) patients with obesity (BMI≥30 kg/m²), group 2 (n = 44) non-obese patients. Healthy individuals (n = 21) - control group. We examined the state of the pro-oxidant-antioxidant balance (PAB) - total hydroperoxides (TH)/total antioxidant activity (TAA). Also, lipid profiles were investigated.

Results: In patients with with CKD and t2DM was found expression of PAB (P <0.05) - decrease in TAA and an increase in TH, with more pronounced indicators been found in obese diabetic patients (P = 0.01); Studying lipid profiles, there were significantly increased proatherogenic lipoproteins (LDL-C, TC, TG) (P <0.05) in obese and non-obese patients compared with healthy individuals. When comparing obese and non-obese patients, a more significant increase in pro-atherogenic lipid fractions was found in obese individuals (P = 0.03). Exploring the relationship between PAB and pro-atherogenic lipid fractions in obese patients with CKD and t2DM, a positive correlation was confirmed (r = 0.45) and (r = 0.55), P <0.05, testifying an association between oxidative stress parameters and hyperlipidemia. It appears that it may be connected with increased lipid peroxidation and, as a result, atherosclerosis progression.

Conclusions: In patients with CKD and t2DM with obesity, a more pronounced imbalance of the pro-oxidant-antioxidant system, increased proatherogenic lipid levels were determined compared to non-obese patients with CKD and t2DM. These results clarify a clear relationship between lipid profiles and oxidative stress parameters in patients with obesity, CKD and t2DM, which may indicate that metabolic disorders - obesity are one of the leading risk factors for the progression of diabetic kidney disease.