Endocrine Abstracts

JOINT270

Introduction: In the Dutch Center of Reference for Prader-Willi syndrome (PWS), we follow over 200 adults with PWS. The majority shows clinical signs of premature aging, starting from the age of 25y. This is in line with the literature, reporting higher prevalences of functional impairment, as well as higher morbidity, higher overall mortality and premature brain aging. Little has been published about dementia in PWS, although some case reports have described dementia in relatively young patients. At cellular level, a significantly shorter leukocyte telomere length (a marker of biological age) has been described in PWS. We have performed a systematic review in order to provide a comprehensive overview of premature aging in PWS, with the aim to develop a PWS-specific geriatric aging score.

Methods: Systematic review (search strategy available upon request) focusing on age related conditions that, in the general population, mainly occur among the people aged 60 or up. Articles about vascular disorders, diabetes mellitus, chronic pulmonary disease, neoplasms including urinary, lung, breast, colorectal and prostatic cancers, cataract and macular degeneration, presbycusis, disorders in de digestive system, rheumatic diseases, prostate diseases and neurodegenerative disorders were included. Also, more specific aging terms like frailty, premature aging, falling, functional decline, dementia, Alzheimer, polypharmacy, osteoporosis, mobility limitation and multimorbidity were included.

Results: The systematic review is currently in progress. We will present a comprehensive overview of key indicators of premature aging, including prevalence of functional decline, metabolic disorders, neurodegenerative conditions, and other geriatric syndromes. Additionally, we will propose a PWS-specific geriatric aging score based on the collected data. These findings aim to enhance our understanding of premature aging in PWS and contribute to improved clinical care strategies for this population.

Conclusion: PWS is characterized by premature aging, starting from the age of 25. Based on our systematic review, we will provide an overview of age related disorders in the Prader-Willi population. We will present a PWS-specific geriatric aging score, which will help us quantify and understand (and in the future possibly prevent) premature aging in PWS.