Endocrine Abstracts

JOINT165

Aim: The study aimed to examine the relationship between serum galectin-3 level in the type with polycystic ovary syndrome (PCOS) and global longitudinal strain (GLS) and aortic intima-media thickness (A-IMT) and whether these measurements are a marker for detecting measurements in the early stages of atherosclerosis and heart failure.

Methods: A total of 80 participants, 40 newly diagnosed PCOS patients and 40 healthy control groups, were included in the Health Sciences University Adana City Training and Research Hospital between 01.06.2021 and 31.03.2022. Galectin-3 level was measured by using Human galectin-3 kits and Enzyme-Linked Immuno Sorbent Assay method. A-IMT and GLS measurements were performed by using ultrasonography and echocardiography.

Results: When both study groups were evaluated, a statistically significant difference was found between the groups in terms of blood glucose, HOMA-IR Index, galectin-3, A-IMT, and GLS values. A correlation analysis was carried out between galectin-3 level and other demographic, clinical and laboratory parameters in the PCOS patient group and control group. Parameters related to Galectin-3 level; GLS were found as A-IMT and HOMA-IR Index. Linear regression analysis was performed using parameters that showed significant correlation with Galectin-3 level. Galectin-3 level was found to be independently associated with GLS.

Conclusion: The study shows that the galectin-3 molecule can be said to detect long-term outcomes such as atherosclerosis and heart failure in a more subclinical period in PCOS patients and that it can help identify the risky patient population, and can be used as a biomarker in diagnosis and follow-up. .

Keywords: Aortic intima-media thickness, galectin-3, global longitudinal strain, polycystic ovary syndrome.