Endocrine Abstracts

JOINT2091

Introduction: Polycystic ovary syndrome (PCOS) is due to a hormonal imbalance of ovarian or central origin, it leads to excessive androgen production, it is responsible for 10% of fertility disorders in women of childbearing age but it can appear earlier in adolescents, it clinically results in cycle disorders, signs of hyperandrogenism, metabolic disorders related to insulin resistance, which is itself secondary to hyperandrogenism with obesity and risk of T2D and later metabolic complications (hypertension, cardiovascular diseases), radiologically it results in polycystic dystrophic ovaries. There is no specific treatment, it is essentially symptomatic, it should be noted that lifestyle plays an important role in the balance of the disease, a 10% decrease in weight could reduce the signs of hyperandrogenism and its complications with the improvement of cycle and fertility disorders.

Material and Methods: In our consultation, we collected 8 adolescent girls with PCOS.

Results: The age of our patients is between 13 and 16 years old, the main reason for consultation was cycle disorders (spaniomenorrhea and sometimes secondary amenorrhea), 6 had obesity to varying degrees, all the patients had signs of hyperandrogenism such as hirsutism, acne, hair loss, etc., 4 had T2D and 7 had a history of cycle disorders in the context of obesity with or without fertility disorders in the mother, the aunts and the cousins. The patients had received different treatments depending on the situation (Dydrogesterone, metformin, hormonal treatment, gynecological advice and lifestyle management). In the 6 patients who managed to reduce their weight, we noted an improvement in cycle disorders with a decrease in signs of hyperandrogenism.

Conclusions: PCOS is a multifactorial pathology where lifestyle and weight management significantly improve the clinical signs in these adolescent girls while remaining cautious about fertility disorders in the future.