ECEESPE2025 ePoster Presentations Metabolism, Nutrition and Obesity (164 abstracts)
Demographic, hereditary, and environmental factors in the development of masld among type 2 diabetes mellitus patients
Yesmine Elloumi 1 , Mouna Elleuch 1 , Khouloud Boujelben 1 , Med Khairi Arous 1 , Hadjkacem Faten 1 , Nadia Charfi 1 , Mouna Mnif 1 , Dhoha Ben Salah 1 & Nabila Mejdoub Rekik 1
1Hedi Chaker University Hospital, Endocrinology Department, Sfax, Tunisia
JOINT463
Background: The development of Metabolic Associated Steatotic Liver Disease (MASLD) in patients with type 2 diabetes mellitus (T2DM) is influenced by a complex interplay of demographic, hereditary, and environmental factors. Understanding these factors is essential for identifying high-risk individuals and improving prevention strategies. We aim to explore specific demographic characteristics, family history, and environmental exposures that contribute to the onset of MASLD in T2DM patients.
Methods: A retrospective study including 202 T2DM patients, followed from 2012 to 2024 at the Endocrinology-Diabetology Department of Hedi Chaker University Hospital in Sfax, Tunisia was conducted. Patients were divided into two groups: Group1 comprised 101 diabetic patients with MASLD while Group2 comprised 101 patients without MASLD.
Results: Demographic factors did not significantly influence the development of steatotic lesions, as both patient groups (Group1 and Group2) shared similar characteristics in terms of age (55 [45-66] years vs. 59 [49-68] years, respectively; P = 0.087) and gender (P = 0.773). Likewise, a family history of cardio-metabolic diseases was not strongly associated with the onset of MASLD, whether it involved early cardiovascular events (P = 0.949), family history of hypertension (P = 0.272), or dyslipidemia (P = 0.239). However, a family history of autoimmune diseases emerged as a significant risk factor for MASLD (P = 0.020). Interestingly, lifestyle factors such as smoking, occasional alcohol consumption, and physical inactivity did not appear to promote steatosis in this cohort (P = 0.525, P = 0.485, P = 0.310, respectively).
Conclusion: These findings suggest that autoimmune history may play a key role in the development of MASLD.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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