Endocrine Abstracts

JOINT1269

Aim: To investigate the influence of different degrees of excess weight on the progression of menopause.

Materials and Methods: The study involved 278 women in the menopausal period, aged 40 to 46 years. The main group (MG) consisted of 218 women with varying degrees of overweight and obesity. The control group (CG) included 60 women with normal body weight and a waist circumference of 80 cm. The severity of climacteric syndrome was assessed using the Greene Climacteric Scale.

Results: The study found that among 218 women in the main group, 62 (28.4%) were classified as overweight (BMI 25.0–29.9 kg/m²), while the rest had varying degrees of obesity (BMI 30.0–41.2 kg/m²). Notably, 72.0% of overweight women reported gaining weight after the age of 36. The prevalence of comorbid conditions was high among individuals with excess body weight, with arterial hypertension observed in 36% of the main group, ischemic heart disease in 22%, chronic venous insufficiency in 10%, and arrhythmias in 10%. Additionally, the occurrence of gynecological disorders correlated with BMI levels. Among overweight women, 58.4% had conditions such as uterine fibroids and adenomyosis, whereas these pathologies were found in only 13.8% of the control group.

Conclusion: In summary, increased central fat accumulation, reduced peripheral fat storage, and ectopic fat deposition contribute to cardiometabolic abnormalities, resulting in a higher prevalence of metabolic syndrome after menopause.