ECEESPE2025 ePoster Presentations Multisystem Endocrine Disorders (51 abstracts)
POEMS sy-a rare etiology of endocrinopathy
Marija Miletic 1 , Milina Tancic Gajic 1 , Milos Stojanovic 1 , Milica Jovanovic 1 , Zorana Arizanovic 1 , Natalija Pavlovic 1 , Taisa Bojovic 1 & Svetlana Vujovic 1
1University Clinic of Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Medical Faculty University of Belgrade, Belgrade, Serbia
JOINT1833
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic premalignant plasma cell disorder that is characterized by the presence of serum M-protein less than 30 g/lor 3 g/dl, bone marrow (BM) clonal plasma cells less than 10%, absence of plasma cell myeloma (PCM) related end-organ damage (CRAB symptoms: hypercalcemia, renal insufficiency, anemia and, bone lesions) and absence of B-cell lymphoma or other disease known to produce an M-protein. MGUS is generally considered a preneoplastic disorder that does not always progress to overt malignancy. Diverse endocrinopathies occur in patients with plasma cell disorders. One possible scenario is the rather rare POEMS syndrome, which is a paraneoplastic syndrome with key manifestations of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. We present a case study which emphasizes the importance of multidisciplinary evaluation of MGUS.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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