Endocrine Abstracts

JOINT568

Introduction: Endocrine diseases are linked not only to physical health issues but also to considerable psychological burdens that can negatively impact patients’ overall well-being. This review seeks to examine different findings in this domain, investigating the connections between hormonal fluctuations and mental health outcomes, while also addressing novel approaches for diagnosis and treatment.

Methods: A systematic search of literature was conducted using the search terms endocrine diseases, mental health, well-being, and psychological interventions.

Results: The central nervous system has receptors for multiple hormones. Dysfunctions of the endocrine system can adversely impact the central nervous system either directly or through the consequences of the endocrine dysfunctions. The relationship between endocrine diseases and mental health has received heightened focus in recent years, as new studies revealed the significant impact that hormonal imbalances can have on psychological well-being. Endocrine diseases such as acromegaly, thyroid dysfunction (hyperthyroidism or hypothyroidism), parathyroid dysfunction (hyperparathyroidism or hypoparathyroidism), adrenal dysfunction (hypercortisolism or adrenal insufficiency), pheochromocytoma, diabetes, and hypogonadism, substantially affect the quality of life of a large number of patients. Most patients experience stress, low mood, and anxiety due to lack of serotonin. These emotions often drive individuals to opt for ultra-processed foods to quickly boost serotonin levels, leading to a vicious cycle and increasing the risk of conditions such as obesity and diabetes. These endocrine diseases disrupt the hormonal balance that regulates autonomic nervous system, cognitive function, stress response, and emotion, resulting in various mental health disorders like cognitive impairment, uncontrollable impulsive behavior, anxiety, depression, and psychosis. In addition to the appropriate treatment of the endocrine dysfunctions, psychological interventions such as cognitive-behavioral therapy and mindfulness-based stress reduction can enhance self-management skills, social functioning, and emotional well-being. The reported studies highlight the necessity of incorporating psychological care into the treatment of patients with endocrine diseases. Subsequent research should concentrate on empirical investigations to substantiate these insights and examine the practical application of the interventions in different clinical settings.

Conclusion: Endocrine diseases substantially affect the quality of life and lead to various mental health disorders such as cognitive impairment, anxiety, depression, and psychosis. The healthcare professionals should identify the underlying factors that may contribute to a patient’s condition, fostering more accurate diagnoses and personalized treatment plans. By addressing the interplay between endocrine and mental health, providers can improve patient’s outcome, enhance quality of life, and promote long-term well-being.