Endocrine Abstracts

JOINT3363

Background: Systemic lupus erythematosus (SLE) is a disease that spreads all over the world. The incidence of SLE in children is 10-20 cases per 100,000 children. Compared with SLE in adults, SLE in children tends to be more severe, requires more intensive care and a higher mortality rate. Growth failure and delayed puberty can also be an effect of SLE in children, caused by severe disease activity and long-term disease duration that can affect the whole body.

Objective: The aim is to understand the effect of systemic lupus erythematosus on pubertal growth and development so that it can help doctors to improve efforts to control systemic lupus erythematosus.

Methods: Total respondents were 23 pediatric patients diagnosed with SLE at dr Saiful Anwar Hospital. Data for each variable studied was obtained through medical records. Puberty status using the Tanner scale, the level of LES disease activity was measured by the SLEDAI Score.

Results: The results showed that the majority of respondents had very high disease activity (39.1%), high disease activity (30.4%), moderate disease activity (21.7%), and mild disease activity (8.7%). Puberty status was found (87%) of normal pubertal development of children and (13%) of delayed pubertal development of children. The results of data analysis using logistic regression showed that there was no relationship between the severity of SLE and the pubertal status (P = 0.249) of children at dr. Saiful Anwar Hospital.

Conclusion: The conclusion is that there is no relationship between the severity of SLE disease and the pubertal status (P = 0.249) of children in dr. Saiful Anwar Hospital.

Keywords: systemic lupus erythematosus, puberty, children, SLEDAI score.