Endocrine Abstracts

JOINT3559

Background: Adult height can be predicted using Bayley-Pinneau (BP) method and BoneXpert software. However, data comparing validity of these methods in Indian children is scarce.

Aim: To assess the accuracy of predicted adult height (PAH) in Indian children with idiopathic short stature (ISS) using BP method and BoneXpert software.

Methods: Children diagnosed with ISS and attending the Pediatrics OPD were identified from clinical records and contacted. Children with ISS and had achieved final adult height (FH) [closure of epiphyses/Bone Age (BA) > 16 years (male)/>14 years (females)] were included, and those with non-availability of BA radiographs and birth weight <2kg were excluded. BA was calculated using GP atlas and BoneXpert software, and PAH was calculated using BP method and BoneXpert software. These PAHs were then compared with their actual FH to assess the accuracy of these prediction models.

Results: A total of 27 cases (12 males) (mean age: 13.7 ± 2.1 years in boys and 11.8 ± 2.2 years in girls) were enrolled for which BA was calculated using GP atlas and predicted adult height (PAH) using BP method. However, BoneXpert could be used for only 25 cases (11 males) as digital x rays were not available for 2 children. BA determination showed good correlation between GP method and BoneXpert (r = 0.85; P <0.001). BP method accurately predicted FH in 8 (6 girls) out of 27 cases with an accuracy of 29.6%. BoneXpert accurately predicted FH in 15 (8 females) out of 25 cases with accuracy of 60%. BoneXpert was more accurate than BP method in predicting adult height (P value= 0.027).

Conclusion: BoneXpert was more accurate than BP method in predicting adult height. Males had significantly greater difference in PAH using BP method compared to females.