Endocrine Abstracts

JOINT3814

Introduction: Metabolic disorders caused by acromegaly are responsible for morbidity three times higher than that of the general population. The objective To analyze the different metabolic complications in acromegalic patients.

Patients and methods: This is a retrospective study of 78 cases of acromegaly followed at the endocrinology department of Ibn Rochd University Hospital from 2005 to 2024. All our patients underwent a metabolic assessment: fasting blood sugar, HbA1c, total cholesterol, HDLc, LDLc, triglycerides with uric acid measurement.

Results: The mean age was 45 years, sex ratio: F/M of: 0.45. The mean BMI rate was 28 kg/m² with overweight in 14 patients (10.9%), and obesity in 26 patients (20.28%). On metabolic assessment: prediabetes in 18 patients (14.04%) and diabetes in 32 patients (24.96%). Dyslipidemia was observed in 41 patients (31.98%) with a mean cholesterol level of 2 g/l, mean triglyceride of 1.69 g/l, mean HDL of 0.41 g/land mean LDL level of 0.99 g/L. Hyperuricemia in 5 patients (6.25%) with a mean uric acid level of 46 mg/L. Treatment of diabetes was based on life style management associated with oral antidiabetics (88%), and insulin therapy + ADO (12%). Patients with dyslipidemia were put on life style management with statins in 58.5%.

Conclusion: Systematic screening of metabolic complications in acromegalic patients and their early and adequate management is of major interest in order to prevent the resulting morbidity and mortality.