Endocrine Abstracts

JOINT2756

Introduction: Central precociuos puberty (CPP) is a premature development of secondary sex characteristics (breast bud before 8 years in girls and enlargement of testicles before 9 years in boys), accompanied with growth and bone age acceleration. The gold standard for diagnosis is stimulated LH above 5 mU/lduring LHRH test. We observed the reports of increased incidence of CPP girls in the last decade.

Aim: To analyze patients with CPP diagnosed and treated in the last 10 years in the University Children’s Hospital.

Methods: The design of the study was a retrospective chart review of patients treated in the University Children’s Hospital between 2014 and 2024. We collected data about their birth history, family history, age at presentation of puberty, auxology data, basic LH, stimulated LH and bone age.

Results: We analyzed the prevalence of CPP patients treated at our hospital in the last decade. The available records revealed below 9 patients before 2019. In 2020 we treated 12 patients, with significant increase in 2021 (24) and stable number in the following years. In the last 5 years we noticed the rise of males with CPP and girls born small for gestational age (SGA). The average age at the initiation of the treatment with GnRH analogue treatment was 7.08 ± 2.21 years. Bone age was fairly advanced in all patients, basic LH was 1.64 ± 1.4 mU/land stimulated LH 12.7 ± 7.7 mU/L. Currently 43 (39 F/4M) patients are receiving GnRH analogue therapy every 3 months.

Conclusion: We noticed increasing numbers of CPP patients in the last decade, especially in the first years of COVID pandemic. The age at presentation remains the same, but we observed increased number of girls born as SGA. We speculate that enlarged number of patients with CPP might be due to obesity rising trend.