ECEESPE2025 ePoster Presentations Reproductive and Developmental Endocrinology (128 abstracts)
Semen cryopreservation and semen quality in transfeminine adolescents prior to hormone therapy
Mohsin Aslam 1 , Pernille Norup 1,2 , Mette Haahr 3,4 , Anne Katrine Pagsberg 3,5 , Annamaria Giraldi 3,4 , Niels Jørgensen 1,2 & Katharina Main 2,3,6
1Copenhagen University Hospital - Rigshospitalet, Department of Growth and Reproduction, Copenhagen, Denmark; 2Copenhagen University Hospital - Rigshospitalet, University of Copenhagen, International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark; 3University of Copenhagen, Department of Clinical Medicine, Copenhagen, Denmark; 4Mental Health Centre Copenhagen, Mental Health Services – Capital Region of Denmark, Copenhagen, Denmark, Sexological Clinic, Copenhagen, Denmark; 5Copenhagen University Hospital, Mental Health Services - Capital Region of Denmark, Child and Adolescent Mental Health Center, Copenhagen, Denmark; 1Copenhagen University Hospital - Rigshospitalet, Department of Growth and Reproduction, Copenhagen, Denmark
JOINT2861
Background: Some transgender individuals wish to become biological parents in the future and transfeminine persons may be offered cryopreservation of semen before starting hormone therapy. However, there is a lack of knowledge about semen cryopreservation outcomes among transfeminine adolescents seeking gender-affirming care.
Aim: To investigate transfeminine adolescents who decide for or against semen cryopreservation.
Methods: This is a retrospective observational national cohort study of 58 transfeminine individuals aged <18 years, assessing clinical data, semen parameters, and reproductive hormone levels.
Results: Among the 58 individuals, 23 (39.7%) opted for semen cryopreservation and successfully collected a semen sample. They were older and more advanced in pubertal development compared to those who did not: median age was 16.4 years (range 13.7-19.4) vs 15.8 years (11.7-17.9), Tanner stage G5 (4-5) vs G3 (2-4), and testis volume 20 ml (15-25) vs 8 ml (3-20). Among 17 individuals with no prior hormone therapy, the median sperm concentration was 11.1 × 106/ml (0.02-163), semen volume 1.8 mL (0.2-3.9), total sperm count 17.8 × 106 (0.1-214.2), and percentage of progressively motile spermatozoa 46% (8-74). Reproductive hormones were within normal ranges for age and sex assigned at birth.
Conclusion: The prevalence of adolescents opting for semen cryopreservation was comparable to other countries with a publicly financed national healthcare system. Overall, semen quality was impaired, which may be attributable to young age, intense gender dysphoria, and lifestyle.
Volume 110
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Endocrine Abstracts
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