Endocrine Abstracts

JOINT1278

Introduction: Polycystic ovarian syndrome (PCOS) is a complex endocrinopathy characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. It affects 5–20% of women of reproductive age worldwide. Its pathogenesis involves oxidative stress (OS), mitochondrial dysfunction, and inflammation. It increases risk for dyslipidemia, fatty liver disease, cardiovascular diseases (CVD), and type 2 diabetes (T2DM). Pharmacological treatments often yield inconsistent results with side effects, highlighting the need for alternative approaches. PCOS is a lifestyle disease, that can be best managed by lifestyle modification like Yoga.

Objectives: To explore the effects of Yoga on metabolic profile in women with PCOS.

Methods: This study involved 80 women (40 diagnosed with PCOS, 40 age and BMI matched healthy control women). PCOS women underwent 12-week Yoga practice (5 days/week, 1 hour/day) including physical postures (Asanas), regulated breathing (Pranayama), and meditation (Dhayana) under a trained therapist. Clinical characteristics and laboratory biochemical data were recorded, followed by a metabolome analysis using LCMS. In addition, the depression scale (BDI-II) and quality of life (WHO-BREF-QOL) were assessed.

Results: Post Yoga intervention we have observed significant improvement in clinical parameters of PCOS women. The metabolome analysis showed 20 significant differentially expressed metabolites (DEMs) involved in the tricarboxylic acid (TCA) cycle, antioxidant pathway, pentose phosphate pathway (PPP), pyrimidine, and tryptophan metabolism, bile acid biosynthesis, urea cycle, mitochondrial electron transport chain, and fatty acid biosynthesis that address key factors of pathogenesis in PCOS. Furthermore, also observed a significant reduction in depression severity and improvement in quality of life after the 12 week regular Yoga practice.

Conclusion: Yoga positively targets key pathological pathway involve in OS, mitochondrial dysfunction, and inflammation. It improves endocrine and reproductive health and lowers the risk of dyslipidemia, CVD, and T2DM. Hence, it can be used as an adjunct for PCOS treatment.