Endocrine Abstracts

JOINT3784

Introduction: Acromegaly is a condition often associated with thyroid diseas. The aim of this study was to analyze the incidence of thyroid nodules, including thyroid cancer, in patients with acromegaly.

Material and Patients: This is a retrospective descriptive study involving 78 acromegalic patients hospitalized in the endocrinology department of CHU Ibn Rochd in Casablanca from January 2005 to December 2024. All patients underwent a morphological thyroid assessment. Statistical analysis was performed using Excel.

Results: The average age of the patients was 48 years (range: 18-72), with a male-to-female ratio of 0.33. The average duration of the disease was 8 years. The average IGF-1 level was 582 ng/ml, which is 2.62 times the normal value. Thyroid morphological abnormalities were found in 52 patients. A multinodular goiter was discovered in 85.7% of patients, while 14.3% of patients had a single nodule. The nodule size was less than 10 mm in 71% of the patients and greater than 10 mm in 22% of the patients. Among these nodules, 46.8% were classified as EUTIRADS 3 and 23,4 % were EUTIRADS 4. Therefore, 39% of our patients underwent fine needle aspiration and 23.4% returned a category 3 result according to the Bethesda classification. Additionally, three cases of papillary thyroid carcinoma were diagnosed.

Conclusion: This study highlights the high prevalence of thyroid abnormalities, particularly multinodular goiter, in patients with acromegaly. The majority of thyroid nodules were classified as moderate to high suspicion of malignancy. underscoring the need for careful monitoring and early diagnosis of thyroid cancer in acromegalic patients. These findings emphasize the importance of regular thyroid assessments in this patient population.