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Endocrine Abstracts (2025) 110 EP1608 | DOI: 10.1530/endoabs.110.EP1608

1Fattouma Bourguiba University Hospital, ENT, Monastir, Tunisia


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Introduction: Hypoparathyroidism is a recognized complication following total thyroidectomy

Aim: to investigate the epidemiological aspects of post-thyroidectomy hypoparathyroidism, including its incidence, risk factors, and duration.

Methods: Retrospective study for over a two-year period (2022-2023) including 100 patients who underwent total thyroidectomy. Data were collected from medical records, including patient demographics (age, sex), surgical indication, postoperative parathyroid hormone (PTH) and calcium levels (day 3 and 1 month post-operatively), hypocalcemia symptoms, and symptom duration.

Results: The study revealed a clear female predominance (female:male ratio of 16:1). The median age was 37 years (range 10-69). The incidence of hypoparathyroidism on postoperative day 3 was 17%, with a median PTH level of 6.2. Only 2 (11.8%) of the 17 patients with hypoparathyroidism exhibited symptomatic hypocalcemia, presenting with paresthesia and calcium levels < 1.8 mg/dl requiring parenteral calcium correction. The remaining 15 patients (88.2%) had mild hypocalcemia and remained asymptomatic. Hypoparathyroidism was most frequently observed in patients operated for papillary thyroid carcinoma (52.9%), followed by multinodular goiter (29.4%). Graves’ disease, benign cysts, and lymphocytic thyroiditis each accounted for 5.9% of cases. At the one-month follow-up, all patients had normal PTH levels, with a median of 33.4. No patients exhibited signs of permanent hypoparathyroidism.

Conclusions: This study provides data on the incidence and risk factors of hypoparathyroidism after total thyroidectomy in our population. The high rate of transient hypoparathyroidism, particularly in patients with papillary thyroid carcinoma, highlights the importance of close postoperative monitoring and surveillance.

Volume 110

Joint Congress of the European Society for Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE) 2025: Connecting Endocrinology Across the Life Course

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