Cardiovascular disease in patients with post-surgical hypoparathyroidism

Sarah Thornhoj; Line Underbjerg; Madsen Lene Ring; Simon Winther; Morten Bottcher; Lars Rejnmark

doi:10.1530/endoabs.110.P211

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Endocrine Abstracts (2025) 110 P211 | DOI: 10.1530/endoabs.110.P211

ECEESPE2025 Poster Presentations Bone and Mineral Metabolism (112 abstracts)

Cardiovascular disease in patients with post-surgical hypoparathyroidism

Sarah Thornhøj^{1, 2}, Line Underbjerg¹, Lene Ring Madsen^{3 4 5}, Simon Winther^{2, 6}, Morten Böttcher^{2, 6} & Lars Rejnmark^{1, 2}

Author affiliations

¹Aarhus University Hospital, Department of Endocrinology and internal medicine, Aarhus, Denmark; ²Aarhus University, Department of Clinical Medicine, Aarhus, Denmark; ³Aarhus University Hospital, Steno Diabetes Center Aarhus, Aarhus, Denmark; ⁴Gødstrup Hospital, Department of Internal Medicine, Herning, Denmark; ⁵Odense University Hospital, Danish Diabetes Academy, Odense, Denmark; ⁶Gødstrup Hospital, Department of Cardiology, Herning, Denmark

JOINT523

Introduction: Hypoparathyroidism (HypoPT) is a rare disorder characterized by hypocalcemia with low levels of parathyroid hormone (PTH). The most common cause of HypoPT is due to neck surgery and is considered chronic if treatment is still needed a year after surgery. PTH has been recognized as a hormone with cardiovascular properties. However, effects of PTH on the cardiovascular system are not well-defined. A previous large retrospective cohort study of patients with chronic HypoPT showed that patients with HypoPT have a significantly higher risk of cardiovascular disease, compared to patients without HypoPT. We aimed to investigate the risk of cardiovascular disease in patients with chronic post-surgical HypoPT.

Methods: Pre-liminary data from a cross-sectional study on 50 patients with chronic post-surgical HypoPT compared to 50 randomly selected people from the general population matched on gender and age (±2 years). All participants underwent blood sampling, coronary computed tomography angiography (CCTA), measurements of pulse wave velocity (PWV) and office blood pressure (BP). Pulse wave velocity was measured using an applanation tonometer (AtCor SpygmoCor-XCEL).

Results: 63 people have consented to participate in the study (35 patients and 28 controls). 56% of these have completed the entire protocol. Mean age of patients were 59 years (31-84 years), 86% female. Duration of HypoPT 13 years (±7 years). Risk factors of cardiac disease (hypertension, smoking, hypercholesterolemia, diabetes) did not differ significantly between groups (p_all > 0. 05). Mean office BT was 124/76 mmHg in patients with HypoPT compared to 125/74 mmHg in controls, P = 0. 96. Mean LDL cholesterol did not differ between groups, P = 0. 32. Mean pulse wave velocity was 8. 49 m/s (95% CI 7. 84; 9. 14 m/s) in patients with HypoPT compared to 8. 88 m/s (95% CI 8. 24; 9. 52 m/s) in controls, P = 0. 42. However, the proportion of HypoPT patients with one or more plaques present in the coronary arteries was 59% (95% CI 39; 78) compared to only 25% (95% CI 3; 65) of the controls, P = 0. 12. The final results await.

Conclusion: Preliminary results suggest that patients with disturbances in calcium homeostasis due to post-surgical HypoPT may have an increased risk of coronary atherosclerosis.