Endocrine Abstracts

JOINT3963

Background and Aim: Emerging scientific data supports the theory that non-syndromic pHPT may be associated to increased risk for various cardiometabolic disorders. The aim of the present study was to decipher the potent role of gender with respect to the impact of pHPT on the lipid and glucose profile of the patients.

Material and methods: A cohort of 227 pHPT (61 male and 166 female) patients from our endocrinology outpatient clinics were included in the retrospective study. Demographic, clinical and laboratory data of these patients were evaluated retrospectively.

Results: The female-to-male ratio was 2. 7:1 with comparable mean age and body mass index among female and male patients (60. 5 vs 58. 4 years, P = 0. 3 and 29. 3 vs 27. 1 kg/m², P = 0. 14, respectively). No significant differences were recorded regarding the parameters of calcium metabolism between the 2 groups. Bone mineral density was lower in both the lumbar spine (P = 0. 033) and the femur neck (P = 0. 029) for female patients. With reference to the lipid metabolism, male patients presented with significantly higher levels of LDL (127vs111 mg/dl, P = 0. 031) and triglycerides (116vs100 mg/dl, P = 0. 04) whilst LpA values were as well more elevated among the male compared to the female patients (38vs31 mg/dl, P = 0. 022). Additionally, the prevalence of arterial hypertension was 55% among men compared to 52% among women (P = 0. 17). Furthermore, diabetes mellitus was more often diagnosed among the male patients (20/61 [32%] vs 40/166 [24. 1%], P = 0. 012). The same observation applied for obesity (P = 0. 024) and impaired fasting glucose (P = 0. 031), which more frequently affected the male group of pHPT patients. Finally, mean uric acid levels were significantly higher among male pHPT patients compared to the female ones (7. 7 vs 6. 7 mg/dl, P = 0. 011), contrary to the CRP levels, which were equal for both groups (P = 0. 24). It should also be highlighted that parathormone levels were strongly and positively associated with both LDL, TGs and Lpa values in both groups of patients, implying no gender difference towards a plausible direct association of the abnormal parathyroid gland function to the lipid metabolism.

Conclusion: Non-syndromic pHPT may be associated with greater risk for concomitant glucose and lipid profile disorders, especially among the male population. Thus, clinicians should be alert and routinely evaluate pHPT patients for the previously mentioned pathological entities in order to promptly diagnose and treat the latter and preserve cardiometabolic health of these patients.