Endocrine Abstracts

JOINT1249

Objective: To investigate the effect of surgical treatment (parathyroid adenoma removal) on the quality of life of patients with primary hyperparathyroidism.

Materials and Methods: Forty patients aged 38 to 65 who underwent parathyroid adenoma removal were examined. The patients were divided into three groups: asymptomatic (8 individuals), manifest (24 individuals), and hypercalcemic (8 individuals). The average parathyroid hormone level before surgery was 454. 7 pg/ml. The quality of life was assessed using the Primary hypoparathyroidism quality of life questionnaire (PHPQoL), which provided quantitative data on 16 indicators related to health status and functional limitations.

Results: Six months after surgery, quality of life assessments revealed that, despite the successful reduction in parathyroid hormone levels, most patients reported symptoms, including pain during prolonged walking 29 (72, 5%), and limitation of recreational activities detected in 24 patients, 67, 5 % patients complained to bone and JOINT pain during prolonged walking, Insomnia during the first three months post-surgery noted in 6 patients and difficulty concentrating at work 10 patients out of 40. These findings suggest that despite successful surgical intervention, a significant number of patients experience symptoms that impair their quality of life.

Conclusion: The study demonstrated that while parathyroid adenoma removal significantly reduces parathyroid hormone levels and improves the overall condition of patients with primary hyperparathyroidism, certain symptoms, such as bone and JOINT pain during prolonged walking, persist in the postoperative period. This indicates the need for further optimization of diagnostic and therapeutic approaches to PHPT to improve patients’ long-term quality of life. Enhancing postoperative care and early rehabilitation may significantly improve the quality of life for these patients.