ECEESPE2025 Poster Presentations Bone and Mineral Metabolism (112 abstracts)
Bone mineralization in children aged 7-10 years born after assisted reproductive technology with frozen and fresh embryo transfer
Elisabeth Waldemar Grønlund 1 , Anna Sophie Lebech Kjaer 1 , 2 , Louise Laub Asserhøj 1 , Ikram Mizrak 1 , 3 , Tine D Clausen 4 , Per Lav Madsen 3 , 5 , Anja Pinborg 1 & Rikke Jensen 2
1Copenhagen University Hospital - Rigshospitalet, The Fertility Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen, Denmark; 2Copenhagen University Hospital - Herlev Hospital, Department of Paediatrics and Adolescent Medicine, Copenhagen, Denmark; 3Copenhagen University Hospital - Herlev Hospital, Department of Cardiology, Copenhagen, Denmark; 4Copenhagen University Hospital - Rigshospitalet, The Obstetrics Clinic, Department of Gynaecology, Fertility and Obstetrics, Copenhagen, Denmark; 5University of Copenhagen, The August Krogh Department of Physiology, NEXS, Copenhagen, Denmark
JOINT3009
Background: Birth weight (BW) is positively associated with Bone Mineral Content (BMC) and Bone Mineral Density (BMD) later in life. Children conceived after assisted reproductive technology (ART) by frozen embryo transfer (FET) have an increased BW compared to naturally conceived (NC) children, while the opposite association is known for children born after ART by fresh-embryo transfer (fresh-ET). Bone health in children born after ART is scarcely explored and with inconsistent Results
Methods: This study was a retrospective cohort study as part of the ‘Health in Childhood following Assisted Reproductive Technology’ (HiCART) cohort, consisting of 606 children (292 boys) aged 7-10 years, conceived after FET (n = 200), fresh-ET (n = 203), and NC (n = 203) born from November 2009 to December 2013. The children were identified through Danish Medical Birth Registry and Danish IVF registry. The clinical examination involved anthropometric measurements, pubertal staging, fasting blood samples, and whole-body dual-energy x-ray absorptiometry scan (DXA). The three groups were compared pairwise using univariate linear regression model and possible confounders and mediators were adjusted for using multiple linear regression analysis.
Results: Crude values of BMC corrected for height did not differ between children born after FET, fresh-ET, or NC. When adjusted for relevant confounders children born after FET had a statistically significant higher BMC corrected for height compared with both fresh-ET and NC. After further adjustment for BW standard deviation score (SDS), the differences in BMC corrected for height disappeared, and no statistically significant differences in BMC corrected for height between any of the three groups was found. Factors potentially affecting bone mineralization, such as calcium, parathyroid hormone (PTH), insulin-like growth factor-I (IGF-I), lean mass, and physical activity in childhood did not differ between the three groups.
Conclusion: Increased BW in children conceived after FET was associated with increased BMC corrected for height at age 7-10 years when compared to children conceived after fresh-ET and NC. This difference was primarily mediated by the higher BW found in children conceived after FET compared with fresh-ET and NC. Longitudinal studies of pregnancies and newborns after FET are needed to explore the causes of the increase in BW and the possible effects on long-term bone health.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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