Endocrine Abstracts

JOINT3667

Introduction: Hypertension is common among primary hyperparathyroidism (PHPT) patients and may contribute to increased cardiovascular morbidity. The impact of parathyroidectomy on blood pressure and cardiovascular outcomes remains unclear and is not typically considered when evaluating a patient for surgery.

Objectives: This study aims to identify predictors of hypertension in PHPT and to assess the impact of parathyroidectomy on blood pressure regulation.

Methods: This observational, retrospective study included 178 PHPT patients at a tertiary center. Logistic regression, adjusted for age, was used to analyze the association between clinical and biochemical variables and hypertension risk.

Results: Our population (84. 8% women, mean age 63 years) showed a hypertension prevalence of 60. 1% (n = 107), with hypertensive patients being significantly older (mean age 67 vs. 57 years, P < 0. 001). After adjusting for age, no significant associations were found between hypertension and calcium, phosphate, PTH, vitamin D, or magnesium levels. Neither chronic renal disease nor disease duration increased hypertension risk. Among hypertensive patients, 60. 7% (n = 65) underwent parathyroidectomy, achieving a PHPT remission rate of 81. 5% (n = 53). At 6 months post-surgery, 7, 5% of patients (n = 4) experienced hypertension remission, and antihypertensive medication usage decreased from 1. 79 to 1. 62 drugs on average (P = 0. 031).

Conclusion: Hypertension is prevalent in PHPT patients, regardless of laboratory values, renal disease, or disease duration. Parathyroidectomy appears to modestly reduce hypertension prevalence and antihypertensive medication use, suggesting long-term cardiovascular benefits.