ECEESPE2025 Poster Presentations Diabetes and Insulin (143 abstracts)
Leukocyte telomere length as a potential indicator of early kidney dysfunction in persons with type 2 diabetes
Viktoriia Yerokhovych 1 , Yeva Ilkiv 1 , Olena Karpenko 1 , Vitalii Gurianov 1 , Dmytro Krasnenkov 2 , Tetiana Tsema 1 , Oksana Sulaieva 3 , 4 , Maryna Bobryk 1 , Iuliia Komisarenko 1 & Nazarii Kobyliak & 3
1Bogomolets National Medical University, Kyiv, Ukraine; 2Institute of Gerontology Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; 3Medical Laboratory CSD, Kyiv, Ukraine; 4Kyiv Medical University, Kyiv, Ukraine
JOINT2974
Background: Leukocyte telomere shortening can occur as a result of both natural age-related changes in the body and various damaging factors. The study of laboratory indicators reflecting age-related changes in chronic kidney disease (CKD) patients serves as an important tool for assessing disease progression and predicting future risk. The search for new markers of kidney damage and factors influencing CKD progression remains highly relevant. Recently, increasing research attention has been given to the role of leukocyte telomere length in various pathological conditions, including systemic inflammation, atherosclerosis, complications of infectious diseases, apoptosis, and aging processes.
Aim: In our study, we examined the relationships between early markers of kidney damage and relative leukocyte telomere length (RTL) in individuals with type 2 diabetes (T2D).
Methods: Our study involved 86 individuals with T2D, who were categorized into two groups on the basis of their estimated glomerular filtration rate (eGFR): Group I (n = 21) with an eGFR < 60 ml/min/m2 and Group II (n = 65) with an eGFR ≥ 60 ml/min/m2. The standardized method proposed by Cawthon et al. was used to measure RTL.
Results: The analysis of RTL in relation to the eGFR revealed a significant difference between the patient groups (1. 10 (0. 97–1. 18) vs 1. 18 (1. 06–1. 41) in group I and group II, respectively; P = 0. 031). A significant positive correlation between RTL and eGFR was observed only in the reduced eGFR group (r = 0. 44; P = 0. 042). In the multivariate logistic analysis, RTL, albumin-to creatinin ratio in daily urine, and T2D duration were found to be independent predictors of decreased eGFR (< 60 ml/min/m2). The AUROC of the model was 0. 79 (95% CI 0. 684 - 0. 897; p <0. 001), with a sensitivity of 71. 4% and a specificity of 73. 8%.
Conclusion: RTL shortening, a longer duration of T2D, and the presence of albuminuria are early prognostic factors independently associated with a decline in renal function in patients with diabetic kidney disease (DKD). Early detection of DKD and an understanding of the predictors of eGFR impairment progression can help reduce the risk of severe complications that significantly impact patients’ quality of life. Timely diagnosis can prevent or substantially slow irreversible changes in the eGFR and enable the initiation of treatment in the early stages of DKD.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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