Endocrine Abstracts

JOINT140

Introduction: Metabolic syndrome (MS), closely associated with visceral fat, is a growing global health concern that also affects individuals with type 1 diabetes (T1D). The estimated glucose disposal rate (eGDR) is a simple and validated tool for predicting MS in patients with T1D. This study aimed to assess the correlation between visceral fat and eGDR.

Methods: We conducted a cross-sectional study including 68 patients with T1D. The study subjects were young adults, aged between 18 and 45 years. Each patient underwent a physical examination (anthropometric parameters and blood pressure), a fasting biological sample collection for the measurement of HbA1c, and lipid parameters and an evaluation of body composition by DXA Scan to measure the visceral fat mass (VFM). Visceral fat mass proportion (%VFM) was calculated by the formula: [VFM (g)/Weight (g)] x 100. High visceral fat mass (HVF) was defined by a %VFM >1, 1 in men and >0, 7 in women. MS was diagnosed according to the International Federation of Diabetes (IDF) criteria.

Results: The study population consisted of 29 men (42. 6%) and 39 women (57. 4%). The mean age was 29. 4±7. 23 years. MS was observed in 14 patients with T1D (20. 6%). HVF was present in 15 patients (23, 4%). The mean eGDR score was 8. 31 ± 1. 72 mg/kg/min, ranging from 2. 81 to 11. 8 mg/kg/min. T1D patients with HVF had lower eGDR (7, 06±2, 01 vs 8, 80±1, 31, P < 0, 001). eGDR was negatively correlated with %VFM (r = -0, 516, P < 0, 001). Using ROC curve analysis, we evaluated the relationship between eGDR and HVF. The area under the curve (AUC) was 0. 775 (P = 0. 001), indicating that an eGDR value below 8. 41 mg kg⁻¹ min⁻¹ was associated with HVF in individuals with T1D, with 71% sensitivity and 73% specificity.

Conclusion: Our study demonstrated that eGDR, with a cut-off value of 8. 41 mg kg⁻¹ min⁻¹, is a reliable marker for estimating visceral fat and can serve as an alternative to DXA scans, especially in situations where DXA is unavailable.