ECEESPE2025 Poster Presentations Diabetes and Insulin (143 abstracts)
Screening of first-degree relatives of children with type 1 diabetes: preliminary results
Ugur Cem Yilmaz 1 , Deniz Ozalp Kizilay 1 , Gamze Yildiz Bas 2 , Burcu Ozbaran 2 , Mehmet Soylu 3 , Raika Durusoy Onmus 4 , İlkay Bahar Balaban Berber 5 , Ahmet Anik 5 , Deniz Erden 6 , Korcan Demir 6 , Elif Gokce Basa 7 , Mert Erbas 7 , Aysun Ata 8 , Sevim Onguner 9 , Berna Eroglu Filibeli 9 , Gunay Demir 1 , Samim Ozen 1 & Damla Goksen 1
1Ege University Faculty of Medicine Department of Pediatric Endocrinology and Diabetes, Izmir, Türkiye; 2Ege University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Izmir, Türkiye; 3Ege University Faculty of Medicine, Department of Medical Microbiology and Immunology, Izmir, Türkiye; 4Ege University Faculty of Medicine, Department of Public Health, Izmir, Türkiye; 5Adnan Menderes University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Aydin, Türkiye; 6Dokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Izmir, Türkiye; 7Dr. Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital, Department of Pediatric Endocrinology and Diabetes, Izmir, Türkiye; 8Afyon Kocatepe University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Afyon, Türkiye; 9Izmir City Hospital, Department of Pediatric Endocrinology and Diabetes, Izmir, Türkiye
JOINT1008
Objective: To screen first-degree relatives of individuals with type 1 diabetes (T1D) for diabetes-related autoantibodies(AAs), identify individuals at increased risk for T1D, and evaluate the psychological impact of screening on both children and their parents.
Methods: This multicenter study targeted the inclusion of 400 children and adolescents aged 2-18 years who were first-degree relatives of individuals diagnosed with T1D. Thus far, 262 participants were enrolled, and screening was completed for 176. Venous blood samples were tested for four autoantibodies (IAA, GAD, IA-2, ZnT8). Psychological assessments were performed using the Screen for Child Anxiety Related Emotional Disorders(SCARED) for children and the State-Trait Anxiety Inventory(STAI-I and STAI-II) for parents, before and after the disclosure of screening Results SCARED scores ≥30 indicated clinical anxiety, 25-30 mild anxiety, and <24 normal. STAI scores >41(state) and >44(trait) signified heightened anxiety.
Results: The mean age of the 176 individuals was 10. 1±0. 34 years, with a gender distribution of 79(44. 9%) females and 97(55. 1%) males. Autoantibody positivity was detected in 17 participants(9. 7%), with one autoantibody identified in 9 individuals(5. 1%), three autoantibodies in 4 individuals(2. 3%), two autoantibodies in 3 individuals(1. 7%), and four autoantibodies in 1 individual (0. 6%). ZnT8 was positive in 13 individuals(7. 39%), anti-GAD in 11(6. 25%), IA-2 in 6(3. 41%), and anti-insulin in 1(0. 57%). SCARED assessment was completed in 61 patients. Anxiety levels increased by 100% in autoantibody-positive children(from 25 to 37, p < 0. 001), while 72% of autoantibody-negative children showed a significant decrease(from 25 to 18, p < 0. 001). The STAI was completed by 53 mothers and 8 fathers. In the autoantibody-negative group, both state(from 38 to 31, p < 0. 001) and trait anxiety(from 39 to 37, P = 0. 007) decreased significantly in parents. In the autoantibody-positive group, state anxiety in parents increased significantly(from 35 to 46, p < 0. 001), while trait anxiety anxiety changed slightly(from 36 to 39, P = 0. 353). Mothers had higher STAI scores than fathers for both state(38 vs. 35) and trait anxiety(35 vs. 28, P = 0. 245).
Conclusion: Among 176 individuals, 4. 54% had two or more positive autoantibodies, which is consistent with findings reported in the literature. This is the first multicenter T1D autoantibody screening in Turkey. Psychological evaluations conducted before and after screening revealed significant anxiety reduction among autoantibody-negative children and their parents, while autoantibody-positive individuals experienced marked increases in anxiety levels. Findings highlight the need to educate at-risk individuals and provide psychological support.
Keywords: Type 1 Diabetes, Autoantibody Screening, Diabetic Ketoacidosis, Psychological Impact
Volume 110
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Endocrine Abstracts
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