ECEESPE2025 Poster Presentations Diabetes and Insulin (143 abstracts)
“Urinary c-peptide to creatinine ratio (UCPCR) as a marker of insulin secretion: impact of glucose load and sex differences”
Sharmaine Reintar 1 , Magdalena Pöchhacker 2 , Anna Ramirez-Obermayer 3 , Katharina Eberhard 4 , Andreas Zirlik 5 , Nicolas Verheyen 5 , Dirk von Lewinski 5 , Daniel Scherr 5 , Barbara Hutz 1 , Christoph Haudum 1 , Thomas Pieber 1 , Harald Sourij 1 & Barbara Obermayer-Pietsch 1
1Medical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology and Endocrinology Lab Platform, Graz, Austria; 2University of Vienna, Department of Food Chemistry and Toxicology, Faculty of Chemistry, Vienna, Austria; 3Medical University of Graz, Clinical Department of Medical Psychology, Psychosomatics and Psychotherapy, Graz, Austria; 4Medical University of Graz, Center for Medical Research, Core Facility Computational Bioanalytics, Graz, Austria; 5Medical University of Graz, Department of Internal Medicine, Division of Cardiology, Graz, Austria
JOINT3159
Background: Insulin resistance and prediabetes are growing risk factors for metabolic and cardiovascular sequelae in many populations worldwide. Early risk detection could be based on biochemical and functional biomarkers for individual diagnosis and monitoring. Therefore, the urinary C-peptide to creatinine ratio (UCPCR) is an emerging diagnostic approach based on a noninvasive tool for assessing and monitoring insulin secretion. This study aims to investigate changes in UCPCR values before and after a defined oral glucose tolerance test (OGTT) and explore potential differences between men and women.
Methods: This study investigated a subgroup of 169 volunteers from the BioPersMed cohort (Biomarkers in Personalized Medicine), with 1022 participants overall. A regular OGTT was performed, with spot urine samples taken before and after the glucose load. In parallel, glucose, insulin, and C-peptide measurements in blood serum or plasma were taken at baseline, 30, 60, and 120 minutes, and a large number of parameters related to metabolic and cardiovascular risk were measured.
Results: Our findings indicate a significant increase in UCPCR following the OGTT compared to fasting values, suggesting that the test induces a measurable change in insulin secretion. We observed no statistically significant difference in UCPCR values between men and women at baseline before the OGTT (P-value 0. 250). However, a notable difference in UCPCR values was found between genders after the OGTT, with women showing higher UCPCR values than men based on the Mann-Whitney U test (P-value <0. 001). Further analyses are ongoing.
Conclusion: These results highlight the dynamic nature of insulin secretion in response to glucose intake and suggest that gender influences UCPCR findings after an OGTT. Further studies in the larger BioPersMed cohort will refine the clinical potential of UCPCR as a biomarker for insulin secretion.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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