Endocrine Abstracts

JOINT573

Intoduction: Glucose values in healthy humans are influenced by many factors like dietary habits, stress and hormonal signaling, lack of adequate sleep.

Aim: To quantify glucose fluctuations in healthy paediatric residents with the use of commercial continuous glucose monitoring systems (CGMS).

Methods: Eligibility criteria for participation in the research were: a)participation as a paediatric resident in the full on-call duty schedule of a Paediatric department in a teritiatory hospital, b)age: 25-40 years, c)absence of chronic disease or receiving treatment affecting glucose metabolism and d)willingness to participate in the study after providing signed consent.

Results: Fifteen sensors were placed in 13 residents (8 females). A total of 35 days of 24-hour duty shift in outpatient basis were covered. Additionally, 35 days were stratified as days after a 24-hour outpatient duty and 114 days were classified as being away from 24-hour outpatient duty shift. In the whole study group, mean glucose values were 99. 69±20. 31 mg/dl, 97. 67±19. 28 mg/dl and 97. 14±16. 99 mg/dl on 24h outpatient duty days, on days after 24h outpatient duty and on days away from 24h outpatient duty respectively (P < 0. 001). Males showed significantly higher glucose values on 24h outpatient duty days in compared to females (101. 22 ± 19. 42 mg/dl vs 99. 17 ± 20. 57mg/dl, P = 0. 006), while on the days after and away from 24h outpatient duty shift, males displayed significantly lower glucose values compared to females (97. 25 ± 19. 24 mg/dl vs 97. 85 ± 19. 30 mg/dl, P = 0. 002 and 96. 57 ± 15. 95 mg/dl vs 97. 12 ± 17. 60 mg/dl, P < 0. 001). The analysis of the data per person individually, showed that the majority of participants significantly increased levels of glucose on the 24h outpatient duty shift (with the exception of 1 male and 1 female resident). Lower glucose values during the night compared to the whole 24 hours for the away from the 24h outpatient duty shifts, were recorded for the majority of participants with the exception of 1 male and 2 3 female participants. On the contrary, higher glucose values were recorded in the night compared to the whole 24 hours in 8 participants (4 males and 4 females) during the 24h outpatient duty shift.

Conclusions: 24h outpatient duty shifts for Paediatric residents have shown that significantly affect glucose values. The stressful environment, lack of sleep and poor and unhealthy dietary habits contribute to this glucose disturbances. Further studies are warranted to confirm and further extent these preliminary data.