Endocrine Abstracts

JOINT2260

Background: The obese children and adults, NAFLD is associated with type 2 diabetes or prediabetes. However, it is unrealistic to have all obese children willing to complete all assessment items.

Objective: To detect the association of type 2 diabetes and prediabetes in obese children with MRI-PDFF proved NAFLD and assess useful screening factors for predicting obese children without NAFLD and prediabetes.

Method: We recruited a cohort of 149 Chinese children/adolescents who finished OGTT test, and 108 children/adolescents with MRI-PDFF evaluated liver fat content. The diagnosis of prediabetes and type 2 diabetes was based on either hemoglobin A1c, fasting plasma glucose or 2 h post-load glucose concentrations.

Result: The prevalence of prediabetes and type 2 diabetes in children/adolescents with obesity was 26. 17% and the OR increased with increasing serum GGT and morning cortisol. There was no significant difference in glucose concentrations at 0 and 120 min in both the prediabetic and non-prediabetic groups with different NAFLD grades. Among factors screened in the comparison between subgroup of NAFLD with prediabetes and subgroup without NAFLD and prediabetes, BMISDS/P90, PLT, ALB, UASDS, ALT, cortisol and HOMA-IR were included for logistic regression analysis. the OR for both NAFLD and prediabetes in obese children increased with increasing serum ALT and PLT. ROC analysis shows ALT lower than 18. 5IU/l had a sensitivity of 85% and specificity of 72. 7% for detecting patients without prediabetes and NAFLD in obese children (ROC AUC 0. 857).

Conclusion: Although prediabetes is highly prevalent among children/adolescents with obesity but was not consistent with the grades of NAFLD. ALT lower than 18. 5IU/l might be useful in deciding not to conduct OGTT test or liver MRI-PDFF after basic examination for children with obesity.