Endocrine Abstracts

JOINT2059

Background: Cardiovascular disease is a frequent cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2D). In adult patients with T2D, it has been observed that the elevation of the triglyceride (Tg)/HDL-C ratio is positively correlated with cardiovascular disease, and that the capacity to promote cholesterol efflux from peripheral cells to HDL is decreased, which is inversely associated with the incidence of cardiovascular disease (CVD). Currently, there are no studies that relate the Tg/HDL-C ratio with the functionality of HDL particles (cholesterol efflux) in adolescent patients with T2D.

Objective: To evaluate the association of the Tg/HDL-C ratio with cholesterol efflux in adolescents with DM2.

Material and Method: This Cross-sectional study included a total of 70 adolescents, 47 of which had T2D treated at the Diabetes Clinic of the Federico Gómez Children’s Hospital of Mexico and 23 healthy adolescents of the same age and sex were included. The protocol was approved by the local Ethics and Research Committees. Anthropometric and biochemical variables (HbA1c, lipid profile, aminotransferases) were determined. Cholesterol efflux capacity (CEC) was determined by measuring the efflux of fluorescently labeled cholesterol from J774 mouse macrophages cells.

Results: In Our study, differences were observed between both groups in the concentrations of glucose (P < 0. 001), total cholesterol (P = 0. 043), triglycerides (P < 0. 001), c-HDL (P < 0. 001), Tg/c-HDL ratio (P < 0. 001), Apo A (P = 0. 029) and GGT (P = 0. 010). When evaluating cholesterol efflux in both groups, no significant difference was observed (P = 0. 600).

Conclusions: In the present study, we found no association between the Tg/HDL-C ratio and cholesterol efflux in adolescents with T2D. Further studies are required to assess whether some cardiovascular risk indices that have already been evaluated in adults would be applicable to the pediatric population with T2D.

Bibliography : 1. Shah AS, Zeitler PS, Wong J, Pena AS, Wicklow B, Arslanian S, et al. ISPAD Clinical Practice Consensus Guidelines 2022: Type 2 diabetes in children and adolescents. Pediatr Diabetes. 2022 Nov;23(7):872-902.

2. Flores-Guerrero JL, Been RA, Shalaurova I, Connelly MA, van Dijk PR, Dullaart RPF. Triglyceride/HDL cholesterol ratio and lipoprotein insulin resistance Score: Associations with subclinical atherosclerosis and incident cardiovascular disease. Clin Chim Acta. 2024 Jan 15; 553:117737.