Endocrine Abstracts

JOINT2247

Objective: Diabetes, marked by elevated blood sugar, raises the risk of serious health issues, including heart and nerve problems, and is linked to a variety of diseases caused by herpesviruses. This study investigates the causal associations between genetically predicted diabetes, its complications, and herpesvirus infections.

Patients: Using summary data from genome-wide association studies (GWAS) on diabetes and herpesvirus infections, the population was primarily of European descent.

Measurements: We employed a bidirectional two-sample Mendelian Randomization (MR) design. Analyses were conducted using the Inverse Variance Weighted (IVW) method, weighted median, weighted mode, and MR-Egger regression. Sensitivity analyses included MR-Egger, MR-PRESSO, Cochran’s Q test, and leave-one-out analysis.

Results: Our Mendelian Randomization study revealed no significant causal association between diabetes and herpesvirus infections. The forward analysis showed odds ratios for Type 2 diabetes and herpes zoster (OR: 0. 99, 95% CI: 0. 92-1. 08, P = 0. 855) and Type 1 diabetes and infectious mononucleosis (OR: 0. 98, 95% CI: 0. 92-1. 04, P = 0. 478) that were not statistically significant. Notably, the IVW analysis showed no significant association between diabetic polyneuropathy and herpesvirus infections, the Weighted Median method suggested a marginal association with herpes zoster (OR: 1. 08, 95% CI: 1. 00-1. 17, P = 0. 05), warranting further research. The reverse analysis also demonstrated non-significant. Sensitivity analyses, including MR-Egger, weighted median, and MR-PRESSO, confirmed these findings, indicating no pleiotropy or outliers affecting the Results

Conclusions: This rigorous MR study provides evidence against a direct causal association between diabetes or its complications and herpesvirus infections, highlighting the need for further exploration into this complex association.