Endocrine Abstracts

JOINT2633

Background: Worldwide prevalence of young onset type 2 diabetes (DM) is showing an increasing trend with the increase in prevalence of pediatric obesity. The prevalence of type 2 diabetes in young Korean population have reached more than 4. 4-fold when compared with the early 2000s. The aim of this study is to investigate factors associated with glycemic control in adolescents with type 2 diabetes to reduce the risk of complications.

Method: Data from adolescents aged 10–19 years who were newly diagnosed with type 2 diabetes mellitus from 2014 to 2023 and had at least one year of follow-up at Korea University Hospital were analyzed. The study compared trends in glycemic control and associated factors, including the patients’ metabolic profile. Patients were classified into good and poor glycemic control groups based on HbA1c in which good glycemic control is HbA1c≤7. 0% and poor glycemic control is HbA1c greater than 7. 0% in addition to those with subcutaneous(SC) insulin injection. Each group were further analyzed for differences in clinical characteristics and laboratory findings

Results: Total of 134 adolescents were newly diagnosed as type 2 DM over 10 years at Korea University Hospital, with mean age of 14. 4±1. 9 years and mean Body Mass Index of 27. 8±5. 5 kg/m2. Mean HbA1c at diagnosis was 10. 6±2. 6% and 81(60. 5%) patients required SC insulin combined with PO medication as initial treatment. Among 93 patients with follow-up duration of 2 years, 47(50. 5%) patients manifested good glycemic control with mean HbA1c of 5. 9±0. 5 and 46(49. 5%) patients had poor glycemic control with mean HbA1c of 8. 6±2. 5%. Patients with poor glycemic control at 2 years had higher AST/ALT, LDL cholesterol, and triglyceride compared with patients with good glycemic control(P < 0. 05). Total of 40 patients required SC insulin injection up to 2 years from diagnosis, and their SPISE index at 2 year was significantly lower than patients treated with PO medication alone or without any medication (4. 8(±1. 3) vs 6. 1(±2. 1), P < 0. 05).

Conclusion: Newly diagnosed type 2 diabetic adolescents showed poor glycemic control at 2 years from diagnosis and presented with metabolic problems confirmed by laboratory Results Close monitoring and proper management of lipid profile as well as glucose level is required to achieve good glycemic control in pediatric type 2 DM patients.