Endocrine Abstracts

JOINT3586

Introduction: Sarcopenia has been proposed as a complication of diabetes. However, there are few body composition studies in type 1 diabetes mellitus (T1DM). Thus, the use of ultrasound as a portable and emerging clinical tool could be useful for the early diagnosis of sarcopenia. Our objectives were to describe ultrasound parameters of body composition in people with T1DM and to determine if there are associations with metabolic variables.

Material and Methods: Cross-sectional study in people with T1DM. Demographic (age, sex), analytical (glycosylated hemoglobin: HbA1c) and clinical variables (total insulin dose (DTI), muscle strength measured with Jamar dynamometer in kilograms (kg) -cut-off point: <p10 of Spanish population-, quadriceps rectus femoris muscle mass and abdominal subcutaneous fat adipose mass (superficial adipose tissue -TASu- and total adipose tissue-TAT-) with ultrasound -Sonosite S-Nerve®) were collected. Statistical analysis was performed with IBM SPSS v. 25.

Results: Fifteen patients with T1DM were evaluated (53% female, mean age 35 ± 12 years, BMI 22. 8 ± 3. 3kg/m2 and mean HbA1c 9. 2±2. 3). Low muscle strength was detected in 28%. The mean rectus femoris quadriceps muscle thickness or Y-axis was 1. 5±0. 3 and its mean area, 5. 6±2. 1. Mean adipose tissue (TAT) was 1. 2±0. 8, mainly dependent on superficial adipose tissue (TASu), with mean 0. 6±0. 4. The Y-axis correlated positively with muscle strength (r = 0. 5, P = 0. 04) and negatively with metabolic control in T1DM (r = 0. 6, P = 0. 03). Worse metabolic control (higher HbA1c) correlated positively with DTI (r = 0. 4, P < 0. 001), TASu(r = 0. 7, P < 0. 001) and TAT(r = 0. 7, P < 0. 001).

Conclusions: In this preliminary study, metabolic control correlated with ultrasound measurements of muscle mass and abdominal adipose tissue. Therefore, the assessment of morphofunctional status seems to be useful and could propose new therapeutic strategies in T1DM.