ECEESPE2025 Poster Presentations Diabetes and Insulin (143 abstracts)
Pancreatic steatosis in newly diagnosed type 2 diabetes: relationships with glycemic control and exocrine function
Tahsin Taner Karaevren 1 , Refika Yorulmaz Kaya 2 , Mahinur Cerit 3 , Halit Şendur 3 , Burak Kalafat 3 , Gizem Yaz Aydın 4 , Özlem Gülbahar 4 , Mehmet Yalçın 2 , Ayhan Karakoç 2 , Müjde Aktürk 2 , Füsun Baloş Törüner 2 , Alev Eroğlu Altınova 2 , Taha Çetin 5 & Ethem Cerit 2
1Gazi University, Faculty of Medicine, Department of Internal Medicine, Ankara, Türkiye; 2Gazi University, Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Türkiye; 3Gazi University, Faculty of Medicine, Department of Radiology, Ankara, Türkiye; 4Gazi University, Faculty of Medicine, Department of Biochemistry, Ankara, Türkiye; 5Gazi University, Faculty of Medicine, Department of Nephrology, Ankara, Türkiye
JOINT1501
Background: Pancreatic steatosis (PS) is characterized by abnormal fat accumulation in pancreatic tissue and is often associated with obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). While its pathophysiology and impact on pancreatic functions have been explored, the interplay between PS, glycemic control, and exocrine dysfunction in T2DM remains inadequately defined.
Objective: To evaluate the presence of pancreatic steatosis, the factors affecting it, and its relationship with endocrine and exocrine pancreatic functions in newly diagnosed T2DM patients.
Methods: A total of 126 individuals were included in the study, comprising 63 newly diagnosed T2DM patients and 63 healthy controls matched for age, sex, body mass index and body fat distribution. Body composition, biochemical parameters (glucose, insülin, C-peptide, HbA1c), fecal elastase levels, and pancreatic/hepatic steatosis grades (evaluated using ultrasonography) were assessed.
Results: Newly diagnosed T2DM patients exhibited significantly higher hepatic steatosis grades (P = 0. 018) and lower fecal elastase levels (P < 0. 001) compared to controls. Pancreatic exocrine insufficiency was more prevalent in the T2DM group (P < 0, 001). A positive correlation was observed between pancreatic steatosis grade, hepatic steatosis grade, and hepatic fat fraction. HbA1c levels demonstrated a nonlinear (inverse U-shaped) relationship with pancreatic steatosis, peaking at 9. 8% and declining thereafter, while showing a continuous negative relationship with fecal elastase levels. HbA1c predicted low fecal elastase (<200 μg/g) with a cutoff value of 7. 4%. Patients with HbA1c levels >9. 8% exhibited reduced pancreatic steatosis alongside persistent exocrine insufficiency.
Conclusions: Pancreatic steatosis is closely associated with hepatic steatosis, glycemic control, and pancreatic exocrine dysfunction in newly diagnosed T2DM patients. Fecal elastase, with an HbA1c cutoff value of 7. 4%, serves as a practical marker for detecting pancreatic exocrine insufficiency. The interplay between pancreatic steatosis, glycemic control, and exocrine dysfunction highlights the need for comprehensive metabolic assessments in this population.
Key words: Exocrine pancreatic insufficiency, fecal elastase, HbA1c, hepatic fat fraction, hepatic steatosis, pancreatic steatosis
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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