Endocrine Abstracts

JOINT1717

Background and Aims: Type 2 diabetes mellitus (T2DM) is a major cause of chronic kidney disease (CKD), affecting 30–40% of diabetic patients. CKD progression increases the risk of cardiovascular disease (CVD), with arterial stiffness playing a crucial role in CVD pathogenesis. Pulse wave velocity (PWV) is a reliable marker of arterial stiffness. This study aims to assess the relationship between arterial stiffness (measured by PWV) and mineral metabolism parameters in T2DM patients with CKD.

Materials and Methods: This cross-sectional study included 105 adult patients with T2DM and CKD, classified into five -stages per KDIGO 2012 guidelines: CKD 1 n = 24, CKD 2 n = 21, CKD 3 n = 25, CKD 4 n = 15, CKD 5 n = 20. Arterial stiffness was assessed using PWV measured at the carotid-femoral level with the SphygmoCor XCEL system. Serum calcium, phosphorus, alkaline phosphatase, vitamin D, parathyroid hormone (PTH), calcitriol, and fibroblast growth factor 23 (FGF-23) levels were analyzed. Statistical analysis was conducted using the Spearman correlation coefficient, with P-values <0. 05 considered significant.

Results: The mean age of participants was 60. 3±8. 1 years, with 58. 1% female. The duration of illness with T2DM was 12. 87±7. 34 years. PWV increased with CKD progression, from 9. 06±2. 20 m/s in CKD stage 1 to 10. 75±2. 34 m/s in stage 5 (P = 0. 004). FGF-23 levels showed a strong positive correlation with PWV (r = 0. 618, P < 0. 001). No significant correlation was found between PWV and serum calcium (r = -0. 098, P = 0. 409), phosphorus (r = 0. 162, P = 0. 169), vitamin D (r = 0. 005, P = 0. 962), or PTH (r = 0. 062, P = 0. 696).

Conclusion: Arterial stiffness, as indicated by PWV, increases with CKD severity in T2DM patients and is strongly correlated with FGF-23 levels. These findings highlight the potential role of FGF-23 as a biomarker for vascular complications in CKD. Further research is needed to elucidate the mechanisms linking FGF-23 and arterial stiffness.