Correlation between inflammation, metabolic syndrom and visceral fat in young type 1 diabetes patients

Samir Mkaouer; Zeineb Rekaya; Meriem Yazidi; Elyes Kamoun; Nadia Khessairi; Ibtissem Oueslati; Fatma Chaker; Melika Chihaoui

doi:10.1530/endoabs.110.P414

P414

Prev Next

Section Contents Cite

Endocrine Abstracts (2025) 110 P414 | DOI: 10.1530/endoabs.110.P414

ECEESPE2025 Poster Presentations Diabetes and Insulin (143 abstracts)

Correlation between inflammation, metabolic syndrom and visceral fat in young type 1 diabetes patients

Samir Mkaouer ¹ , Zeineb Rekaya ¹ , Meriem Yazidi ¹ , Elyes Kamoun ¹ , Nadia Khessairi ¹ , Ibtissem Oueslati ¹ , Fatma Chaker ¹ & Melika Chihaoui ¹

Author affiliations

¹Chu La Rabta, Endocrinology Department, Tunis, Tunisia

JOINT312

Introduction: Insulin resistance (IR), feature of type 2 diabetes, is an inflammatory state that promotes atherosclerosis and increases cardiovascular mortality. IR is often underrecognized in young adults with type 1 diabetes (T1D). The aims of this study were to determine the prevalence of IR in young T1D and evalue the inflammatory status of T1D with IR.

Methods: We conducted a cross-sectional study including 68 T1D. The study subjects were young adults, aged between 18 and 45 years. Each patient underwent a physical examination (anthropometric parameters and blood pressure), a fasting biological sample collection for the measurement of HbA1c, lipid parameters and C reactive protein (CRP), an evaluation of body composition by DXA Scan which measured the the visceral fat mass (VFM). Proportion of visceral fat (PVF) was calculated using the formula: PVF = (VFM/weight)*100 High visceral fat levels (HVF) was defined by a PVF >1, 1 in men and >0, 7 in women. MS was diagnosed according to the International Federation of Diabetes (IDF) criteria.

Results: The study population consisted of 29 men (42. 6%) and 39 women (57. 4%). The mean age was 29. 4±7. 23 years. The median duration of diabetes was 11 years (4. 2–17. 0), with a range from 1 to 29 years. MS was observed in 14 patients (20. 6%). HVF was present in 15 patients (23, 4%). CRP levels were higher in T1D patients with MS (2. 6 mg/l [1. 85–5. 5]) compared to those without MS (1. 6 mg/l [1–3. 8]), with a P-value of 0. 068. CRP levels were Significantly higher in T1D patients with MS (3, 85 mg/l [1, 92-6, 77]) compared to those without MS (1, 45 [1, 00-3, 02]) with a P-value of 0, 006.

Conclusion: Although inflammation due to IR was well established in the general population and type 2 diabetes patients, it is less studied in T1D patients. In our study, the inflammation measured by CRP, was more strongly correlated in T1D with HVF than MS. Indeed the visceral fat, promotes the development of chronic low-grade inflammation by secreting cytokines like IL-1, IL-6, TNF-alpha, and leptin.