Endocrine Abstracts

JOINT3878

Introduction: Pancreatic diabetes, or Type 3c diabetes by the ADA, is secondary form of diabetes caused by primary pancreatic disorders damaging the Islets of Langerhans, leading to endocrine dysfunction of the pancreas. Often misdiagnosed as Type 1 or Type 2 diabetes, it presents certain characteristics that make it markedly different in terms of causes, clinical presentation, treatment, and prognosis.

Objective: The aim of our study is to highlight the various clinical, biological, and morphological aspects that can suggest the diagnosis of pancreatic diabetes in certain patients.

Patients and Methods: Descriptive retrospective study, including 145 patients hospitalized in our department for newly diagnosed diabetes between September 2018 and December 2024.

Results: The study included 106 men and 39 women, with a sex ratio of 2. 79. The average age was 48 years, and 37. 5% had a family history of diabetes. Some patients reported toxic habits, including smoking. Clinically, the average BMI was 20. 4, with an average weight of 60 kg. The duration of diabetes did not exceed one year in any of the patients, with an average weight loss of 14. 6 kg. Biologically, an elevated CA 19-9 level was found in 37. 5% of cases. All patients underwent a CT scan, which identified pancreatic tumor lesions with varying locations.

Conclusion: Pancreatic diabetes, although previously considered rare, is increasing in adults in their fifties, presenting with rapid onset of diabetes and significant weight loss. Suspecting this condition requires further appropriate investigations to confirm the diagnosis.