Endocrine Abstracts

JOINT2650

Background: Type 2 diabetes mellitus (T2 DM) is a leading cause of morbidity and mortality in children. Identification in the early-stage lead to better outcome and lesser intervention. Risk factors predisposed to progression of pre-diabetes needs to be identified.

Aim: To identify the course and outcomes the progression from prediabetes to Type 2 Diabetes Mellitus (T2 DM) in Indian children and adolescents.

Methodology: 90 Indian children and adolescent (Boys 68. 9%, Mean age 13. 2 + 3. 3 years) were followed up. Baseline fasting blood glucose (FBS) and 2 Hours oral glucose tolerance test after 1. 75gm/kg glucose (OGTT) was done to identify pre-diabetes in children. Metabolic profiles were also analyzed. At the last follow-up they were again evaluated for glycemic profile and other metabolic complications.

Result: A total of 90 children were followed up for a mean duration of 2. 3 ± 1. 7 years. Of these, 60 children (66. 7%) were cured, while 30 children (33. 3%) remained dysglycemic. Among the 30 dysglycemic children, 8. 9% progressed to diabetes, while 24. 4% remained prediabetic. Children with a family history of diabetes had an odds ratio of 2. 8 for progression to diabetes. The cured group showed a significant reduction in BMI SDS (P = 0. 008) and percentage BMI (P = 0. 02) compared to the disease group.

Conclusion: The findings indicate that a family history of diabetes may be a significant predictor for the progression of prediabetes in Indian children. Furthermore, a reduction in BMI SDS is linked to the potential resolution of prediabetes.