ECEESPE2025 Poster Presentations Endocrine Related Cancer (76 abstracts)
Patient reported outcome measurements (PROM) for the evaluation of the psychosomatic status in patients with adrenocortical carcinoma
Otilia Kimpel 1 , Senta Kiermeier 2 , Emely Stahl 3 , Barbara Altieri 4 , Martin Fassnacht 5 & Imad Maatouk 2
1Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, University of Würzburg, Würzburg, Germany; 2Section of Psychosomatic Medicine, Psychotherapy and Psychooncology, Department of Internal Medicine II, Julius-Maximilian University Würzburg, Würzburg, Germany., Würzburg, Germany; 3Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, University of Würzburg, Germany, Würzburg, Germany; 4Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, University of Würzburg, Germany, Bavarian Cancer Research Center (BZKF), University Hospital, University of Würzburg, Germany, Würzburg, Germany; 5Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, University of Würzburg, Germany, Bavarian Cancer Research Center (BZKF), University Hospital, University of Würzburg, Germany, Comprehensive Cancer Center Mainfranken, University of Würzburg, Germany, Würzburg, Germany
JOINT1992
Background: Several studies have shown that distress, depression and fear of progression (FoP) are common in cancer patients and negatively impact quality of life (HRQoL). However, no studies have explored these aspects in patients with adrenocortical carcinoma (ACC).
Objectives: This observational study investigates FoP, distress and depression in patients with ACC and their impact on HRQoL.
Methods: Adults (≥18 years) with ACC were included during regular hospital visits. Patients filled out questionnaires addressing FoP (FoP-questionnaire, short-form), HRQoL (EORTC-QLQ-C30), distress (National Comprehensive Cancer Network distress thermometer) and depression (patient health questionnaire, PHQ-9). Patients were distributed according to different clinical parameters to assess possible influencing factors. Multiple linear regression on HRQoL subscales (‘total symptoms’, ’total functioning’) was performed in order to identify associated psychosomatic variables.
Results: Over a 12-months period, 105 patients were included (56. 2% female; median age = 49 years). Most patients demonstrated an elevated level of distress (62%) and a high level for FoP (59%). A major depression according to PHQ-9 was present in 41% of participants. The HRQoL questionnaire showed a higher level for functional problems (median = 62. 2) in comparison to symptoms (median = 33. 3). These results were neither influenced by tumour burden, hormone secretion nor by cancer treatment. In the multiple linear regression only depressive symptoms revealed a significant effect for HRQoL ‘total symptoms’ (Bstand = 0. 620, P<. 001) and for HRQoL ‘total functioning’ (Bstand = -0. 673, P<. 001). Most of our patients (80%) showed a need for psychosomatic counselling revealed by the questionnaires.
Conclusions: Patients with ACC show similar values for distress, FoP, depression and HRQoL independent of their clinical characteristics. The questionnaires revealed the need for psychosomatic intervention that should be offered to all patients with ACC.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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