ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
Hepatic triglyceride export in acromegaly and the effects of treatment - a preliminary study
Clemens Baumgartner 1 , Matthaeus Metz 1 , Marianna Beghini 1 , Lorenz Pfleger 1 , Anna Tosin 1 , Oliver Koldyka 1 , Hannes Beiglboeck 1 , Paul Fellinger 1 , Greisa Vila 1 , Anton Luger 1 , Alexandra Kautzky-Willer 1 , Angelika Freudenthaler 1 , Sabina Baumgartner-Parzer 1 , Herbert Stangl 2 , Martin Krssak 1 , 3 , Thomas Scherer 1 , Michael Krebs 1 & Peter Wolf 1
1Medical University of Vienna, Internal Medicine III, Vienna, Austria; 2Medical University of Vienna, Institute of Medical Chemistry, Center for Pathobiochemistry and Genetics, Vienna, Austria; 3Medical University of Vienna, High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Vienna, Austria
JOINT1896
Overview: High growth hormone (GH) concentrations are associated with low intrahepatic lipids (IHL). Lately, our study group reported a GH mediated stimulation of hepatic triglyceride (TG) export in healthy males as possible antisteatotic mechanism. However, the impact of long-term GH excess in acromegaly on hepatic TG export is yet unknown.
Methods: For this preliminary analysis, GH/IGF-I axis activity and hepatic TG secretion were investigated in 8 patients with active acromegaly (4 female, median 52 [IQR: 44-55] years, BMI 28. 1 [26. 5-31. 9] kg/m2). Hepatic TG secretion was assessed via an intralipid infusion protocol and IHL were measured using magnetic resonance spectroscopy. In 5 Patients, measurements were repeated after successful treatment. Data before treatment were compared to an unmatched group of 9 male volunteers (23 [22-27] years, BMI 21. 2 [20. 2-25] kg/m2) with low IHL.
Results: IHL content was comparable between patients with acromegaly and controls (1. 2 [1. 1-1. 4] vs. 0. 9 [0. 8-1. 4] %, P = 0. 556). Hepatic TG secretion was not increased in active acromegaly (patients vs controls: 577 [483-738] vs 436 [401-785] mg/h, P = 0. 336). Successful treatment of acromegaly did not significantly reduce hepatic TG secretion (577 [483-738] vs 475 [393-634] mg/h, P = 0. 242). Data for IHL was present for 6 patients before and 3 patients after treatment initiation (1. 2 [1. 1-1. 4] vs. 0. 9 [0. 7-1. 3] %).
Conclusion: According to this preliminary analysis, low IHL in acromegaly is not associated with a substantial increase in hepatic TG secretion. These findings are in contrary to previous investigations of healthy individuals during short-term GH/IGF-I axis modulation. Further studies will need to clarify possible adaptations in hepatic lipid metabolism after long-term GH excess.
Volume 110
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Endocrine Abstracts
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