ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
Impact of a 4-week multidisciplinary prehabilitation program on tumor-related gene expression in patients with colon cancer: the ONCOFIT project
Juan Luis López-Cánovas 1 , Manuel Fernandez-Escabias 1 , Andrea Orellana-Jaen 1 , Sofia Carrilho-Candeias 1 , Cristian Garcia-Sanchez 1 , Maria Tomas-Garcia 1 , Rodrigo Fernandez-Escabias 1 , Alberto Millan-Martin 1 , Benito Mirón 2 , Teresa Nestares 3 , 4 , Manuel D. Gahete 5 6 7 & Francisco J. Amaro-Gahete 1 5 8
1Department of Physiology, Faculty of Medicine, University of Granada, Sport and Health University Research Institute (iMUDS), Granada, Spain; 2Service of Surgery, San Cecilio Clinical University Hospital, Granada, Spain; 3Department of Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain; 4Biomedical Research Centre (CIBM), Institute of Nutrition and Food Technology "José Mataix", University of Granada, Granada, Spain; 5CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Institute of Salud Carlos III, Madrid, Spain; 6Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofía University Hospital, Córdoba, Spain; 7Department of Cell Biology, Physiology and Immunology, University of Córdoba, Córdoba, Spain; 8Biosanitary Research Institute, Ibs. Granada, Granada, Spain
JOINT1088
Obesity is one of the key factors associated with colon cancer development independent from inherited genetic mutations. Furthermore, obesity-related unhealthy lifestyle behaviors (e. g., low physical activity and fitness or an unhealthy diet) significantly increase the risk of postoperative complications in patients undergoing surgery, the first-line treatment for colon cancer. These complications affect more than 50% of patients, leading to higher morbi-mortality rates, increased healthcare costs and a reduced quality of life. For that, lifestyle-based prehabilitation multimodal programs (PMP) (exercise, dietary behavior changes and psychological support) have been proposed to improve physiological reserve and postoperative recovery, and to reduce risk factors for cancer recurrence. However, the molecular mechanisms underlying these types of interventions remain unexplored. The aim of this study was to analyze the effects of a 4-week PMP on the expression of key tumor-related genes in patients undergoing resection of colon cancer. For this purpose, we analyzed mRNA expression of 93 genes (microfluidics-based qPCR array) involved in tumor environment, development and progression (e. g., tumor markers, inflammation, immune system, or energy metabolism) in tumor and non-tumoral adjacent tissues from patients with colon cancer (n = 48; including both men and women) randomly assigned to a PMP (n = 23) or a usual care (n = 25). Statistical associations with key clinical features of colon cancer were performed. The results revealed a significant beneficial regulation of the pattern of genes expression in patients undergoing PMP, which have been previously described to be altered in the context of this pathology. These beneficial patterns include genes (i) involved in the regulation of intracellular calcium (CALB2), (ii) associated with inflammation and immune response regulation (TGFB1, VASN, TNFa, IL6ST, IL6R, PTGS2, and SPP1), (iii) potent growth factors promoting cell proliferation, survival, and differentiation (IGF1 and IGF2), (iv) related to metastatic processes in the liver and lungs (CXCL12), and (v) involved in tumor suppression and apoptosis (TP53 and BCL2), among others. Additionally, many of these genes were correlated with pivotal clinical and histopathological parameters, such as body weight or tumor volume. In conclusion, a 4-week PMP modulates the expression of relevant cancer-related genes in patients with colon cancer compared with those receiving usual care. These changes correlated with clinical parameters of the patients. Although further research is needed in this area, this transcriptional regulation may help explain the beneficial outcomes observed with the PMP in the ONCOFIT Project.
Fundings MICINN (PID2023-147665OA-I00; JDC2022-049274-I); CIBERobn.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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