ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
The visceral adipose-derived hormone ANNEXIN A8 alleviates obesity-induced chronic inflammation via modulating macrophage functions
Ping Gu 1 , Xuemei Zhao 2 , Wei Wang 1 , Bin Lu 1 & Jiaqing Shao 1
1Nanjing Jinling Hospital, Nanjing, China; 2School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
JOINT448
Obesity is a major risk factor for a panel of chronic diseases and thus is becoming a major challenge worldwide. In particular, abnormally high level of visceral adipose tissue (VAT) deposition, known as visceral obesity, is an independent risk factor for metabolic diseases. We found that Annexin A8 (Anxa8) gene is selectively induced in VAT of obese mice. The transcription of ANXA8 is induced by hypoxia. Mice with adipocyte-selective deletion of Anxa8 are more susceptible to diet-induced glucose intolerance and chronic inflammation. Simillarly, neutralization of circulating ANXA8 exacerbates diet-induced metabolic diseases. Conversely supplementation of recombinant ANXA8 protein protects mice against diet-induced glucose intolerance and chronic inflammation. Mechanistically ANXA8 directly modulates macrophage polarization via activation of AMPK pathway. In human serum ANXA8 concentration was positively correlated with VAT amount, and VAT/SAT ratio, but was less correlated with subcutaneous adipose tissue (SAT).
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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