ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
The effect of GLP-1 administration on food intake in people with weight regain post-metabolic surgery
Kleopatra Alexiadou 1 , Kavita Narula 1 , Khalefah Malallah 1 , Carolina Coimbra de Brito Lobato 1 , Anna Kowalka 1 , Sanjay Purkayastha 1 , Christos Tsironis 2 , Patricia Ortega 2 , Sherif Hakky 2 , Louisa Brolly 2 , Samantha Scholtz 2 , Lucy Tweedlie 2 , Harvinder Chahal 2 , Karen O’Donnell 2 , Candace Bovill-Taylor 2 , Anna Sackey 2 , Rhian Houghton 2 , Saira Hameed 2 , Chioma Izzi-Engbeaya 1 , 3 , Ahmed Ahmed 2 & Tricia Tan 1
1Imperial College London, London, United Kingdom; 2Imperial College Healthcare NHS Trust, London, United Kingdom; 3Imperial College Healthcare NHS Trust, Department of Endocrinology, London, United Kingdom
JOINT2805
Background: Metabolic surgery remains the most effective option for sustainable weight loss. Sleeve gastrectomy is one of the commonly performed procedures. However, the percentage of people who fail to lose weight after surgery or regain weight ranges between 20–30%. Depending on the definition, category and surgery type, this percentage can vary between 3. 9 to 71%. The mechanisms behind the divergent responses to metabolic surgery are not fully understood. We hypothesised that people who regain weight after initial successful weight loss with sleeve gastrectomy might exhibit a resistance to the anorectic effects of GLP-1, the post-prandial secretion of which is known to be markedly stimulated by metabolic surgery.
Subjects and Methods: Ten patients who lost more than 20% of their pre-operative weight and sustained it after Sleeve Gastrectomy (“good responders”) and nine patients who lost more than 20% of their pre-operative weight at nadir but then regained weight (“regainers”), were enrolled in a single blinded study. The participants received two subcutaneous infusions at random order, one placebo infusion and one GLP-1(7-36) •NH2 infusion for 4. 5 hours. An ad libitum meal study was performed 4 hours after the initiation of each infusion. Participants were asked to eat a large portion of a standardised meal until they were comfortably full. Food intake was the primary outcome.
Results: Both the good responders and regainers significantly reduced their food intake during the GLP-1 infusion compared to placebo (P = 0. 038 and P = 0. 047 respectively).
Conclusions: People who regain weight after initial successful weight loss after Sleeve Gastrectomy retain sensitivity to GLP-1 treatment similarly to the people who have achieved successful and sustainable weight loss. This finding suggests that adjunctive treatment with GLP-1 analogues may play a role in managing weight regain after metabolic surgery.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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