Endocrine Abstracts

JOINT2220

Objective: To investigate the correlation between urinary n-acetyl-α-D-glucosaminase(NAG)and serum cystatin C(Cys-C)levels and physical measurements, glucose and lipid metabolism, liver and kidney function and other indicators in children with simple obesity. To further explore the clinical significance of urinary NAG and serum Cys-C levels in the assessment of early renal damage in children with simple obesity.

Methods: 302 children with simple obesity were selected, (110 cases in the mild to moderate obesity group and 192 cases in the severe obesity group)and 53 children of similar age were selected as the normal control group. Clinical data of the two groups, were collected to compare the differences in clinical data between the obese group and the normal control group, and to analyze the correlation between blood Cys-C, urine NAG and renal function. In addition, 302 children with simple obesity were divided into albuminuria group and normal albuminuria group according to urnie albumin creatine raio (UACR) ratio. The differences of general clinical data and laboratory parameters among albuminuria group and normal albuminuria group were compared. Multivariate Logistic regression analysis was used to find out the predictors of kidney damage, and ROC curve was used to verify them.

Results: 1. There were statistically significant differences in eGFR, mALB and uNAG in the mild to moderate obesity group, the severe obesity group and the normal control group(P<0.01).

2. Cys-C, uNAG, eGFR, BUN and UA in obesity 0-2 years, 2-5 years and ≥5 years course groups were higher than those in control group, with significant statistical difference (P < 0.01).

3. ROC curve: the combined detection of uNAG and Cys-C had the largest area under the curve (AUC=0.8167), and the specificity and sensitivity were higher (75% and 85.7%).

Conclusions: 1. The levels of uNAG and Cys-C in children with simple obesity are higher than those in normal children, suggesting that early kidney damage may occur in children with simple obesity.

2. uNAG is an independent factor of early kidney injury in children with simple obesity. The combined detection of uNAG and serum Cys-C is superior to the single detection of uNAG.