ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
Serum and liver lipidome following empagliflozin administration for six months in a fast food diet mouse model
Evangelia Makri 1 , Thomai Mouskeftara 1 , Helen Gika 1 , Konstantinos Xanthopoulos 1 , Eleftheria Makri 1 , Panagiotis Mavrommatis-Parasidis 1 , Anastasia Tsingotjidou 1 , Angeliki Cheva 1 , Antonis Goulas 1 & Stergios Polyzos 1
1Aristotle University of Thessaloniki, Thessaloniki, Greece
JOINT717
Empagliflozin is a sodium-glucose co-transporter inhibitor approved for the treatment of type 2 diabetes mellitus. The aim of this study was the 6-month effect of empagliflozin on serum and liver lipidome in C57BL/6J mice (EMPA group) fed on fast food diet (FFD) compared with a group fed on FFD without empagliflozin (FFD group) and another control group fed on a chow diet (CD group). Following untargeted lipidomics analysis, FFD and EMPA groups displayed similar serum lipid profiles, characterized by elevated levels in most of the identified lipids, particularly glycerophospholipids, compared to the CD group. Conversely, hepatic lipid profiles varied more significantly between the groups. For example, phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylglycerol demonstrated mixed trends in the FFD and EMPA groups compared with the CD group. FFD appears to have a more substantial impact on lipidomic profiles compared with the preventive empagliflozin effect (CV ANOVA=3.43×10−6 FFD vs. CD; 7.67 × 10−7 EMPA vs. CD; 2.00 × 10−2 EMPA vs. FFD). Interestingly, several glycerophospholipids, including PC 34:1, PC 35:1, PC 36:3, PC 38:4, PI 34:2 and PI 38:3, increased in both serum and hepatic tissues of the FFD and EMPA groups compared to the CD group. In conclusion, EMPA had largely similar lipidomic profile compared with FFD. However, both EMPA and FFD groups showed distinct lipidomic profiles compared to the CD group.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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