Endocrine Abstracts

JOINT3888

Background: Obesity is considered as the most important public health concerns of the current century. Obese children have increased risk for multiple disorders, one of the most important risks is cardiovascular effects and insulin resistance. Epicardial fat, like any other adipose tissue, can contribute to the formation of atheroscelrosis and aggravation of IR by increasing free fattyacids and cytokines. The imbalance of cardioprotective and unfavorable adipokines released by the epicardial fat is closely associated with the development of coronary arteriosclerosis and other cardiac threats in the obese population.

Objectives: The study aimed to assess the impact of obesity on epicardial fat thickness (EFT) and to identify the risk factors that affect the EFT in this cohort.

Methods: The study enrolled 80 obese children and adolescents compared to 20 healthy controls. Detailed history and examination were studied. Anthropometric measurement and vital signs were assessed. Echocardiography was done for assessment of EFT in the parasternal long axis view. Lipid profile was assessed.

Results: In the current study, 80 obese children were compared to 20 healthy controls. echocardiography showed higher EFT in both obesity groups compared to lean subjects. Female patients and dyslipidemia were associated with increased EFT in obese patients.

Conclusion: Obesity in children can cause early subclinical cardiovascular changes which are prominent through its effect on epicardial fat thickness.