ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
The association of ciruculating spexin, obesity, and metabolic parameters in Korean children and adolescents
Shin-Hee Kim 1 , Sung Eun Kim 1 , Seulki Kim 2 , EUNHA BAE 3 , Su Jin Park 3 , Soo Yeun Shim 3 , Moon Bae Ahn 3 , Won Kyoung Cho 4 , Kyoung Soon Cho 5 , Min Ho Jung 6 & Byung-Kyu Suh 3
1Department of Pediatrics, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Pediatrics, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 3Department of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 4Department of Pediatrics, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 5Department of Pediatrics, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 6Department of Pediatrics, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
JOINT1022
Background: This study aimed to determine the correlation between circulating spexins, obesity, and metabolic parameters in children and adolescents in South Korea.
Methods: This single-center study included 128 Korean children and adolescents: 65 (50.8%) were obese, 47 (36.7%) were overweight, and 16 (12.5%) were normal weight. Metabolic parameters were measured, including fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and lipid profiles.
Results: Spexin levels were significantly lower in obese children than in controls (mean 163.1 vs. 198.4 pg/mL; P = 0.01). Spexin levels were lower in the IR group than in the non-IR group (mean 145.3 vs. 185.1 pg/mL; p < 0.001). Spexin levels were not associated with sex or pubertal stage. Spexin levels were negatively correlated with BMI SDS (r = -0.30; p < 0.001), systolic BP (r = -0.33; p < 0.001), fasting insulin (r = -0.41; p < 0.001), HOMA-IR (r = -0.42; p < 0.001), TG (r = -0.38; p < 0.001), and plasma leptin levels (r = -0.26; P = 0.004). Multiple linear regression analysis indicated that after adjusting BMI SDS, plasma spexin levels were independently associated with HOMA-IR (P < 0.001) and TG (P < 0.001). Mediation analysis indicated that the effect of BMI SDS on HOMA-IR was partially mediated by spexin levels.
Conclusions: This study demonstrated an association between plasma spexin level, obesity, and insulin resistance in Korean children and adolescents.
Volume 110
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Endocrine Abstracts
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