ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
Higher BMI as a protective factor for the development of ketotic hypoglycaemia in children with vomiting and dehydration
Juraj Stanik 1 , 2 , Simona Tarnokova 3 , Lenka Langerova 1 , Sabina Szoradova 1 , Barbora Pitekova 4 & Tomas Dallos 1
1Medical Faculty of Comenius University, National Institute for Children´s Diseases, Department of Paediatrics, Bratislava, Slovakia; 2Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Department of Metabolic Disorders, Bratislava, Slovakia; 3National Institute for Children´s Diseases, Department of Laboratory Medicine, Bratislava, Slovakia; 4National Institute for Children´s Diseases, Department of Emergency Medicine, Bratislava, Slovakia
JOINT1577
Background: Healthy children from 7 months to 7 years are known to be at risk for developing hypoglycaemia during prolonged fasting, particularly during acute illness with decreased oral intake. The aim of our study was to identify additional risk factors for hypoglycaemia in children with acute vomiting and dehydration.
Methods: A retrospective analysis included 560 healthy children and adolescents (aged from 29 days to 17.96 years) without known metabolic disorders admitted to hospital with dehydration due to the acute illness with vomiting or poor oral intake. As potential risk factors of hypoglycaemia historical and anthropometric parameters were evaluated.
Results: One hundred seventy-one (30.5%) participants (aged 0.6-10.7, median 3.8 years) experienced hypoglycaemia ≤3.3 mmol/l. In a multiple logistic regression analysis, beside known factors such as higher degree of dehydration and complete absence of oral intake, other independent predictors of hypoglycaemia were a history of diarrhoea, lower BMI and lower BMI-SDS, but not age. Hypoglycaemic children had BMI 12.0-19.3 kg/m2, BMI-SDS from -2.25 to 1.9, and only one child was obese with BMI-SDS 1.9. The highest frequency of hypoglycaemia (37.5-51.6%) was observed in the age groups of 2-7 years, who also had low median BMI values (13.9-14.8).
Conclusions: We identified low BMI, low BMI-SDS and diarrhoea as risks factors for developing hypoglycaemia. The typical shape of the BMI curve in children with physiologically low values at 2-7 years of age could partly explain the high incidence of hypoglycaemia in otherwise healthy children with decreased oral intake at this age. Supported by: VEGA1/0659/22.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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