ECEESPE2025 Poster Presentations MTEabolism, Nutrition and Obesity (125 abstracts)
Comparison of ambulatory glucose profile (AGP) parameters between two advanced hybrid closed-loop (AHCL) systems from childhood to adulthood at 6 and 12 months
Enrico Saudelli 1 , Giulio Maltoni 2 , Gianmarco Pizza 1 , Anna Malaguti 1 , Alessia Bruco 1 , Michele Baldari 1 , Laura Tribotti 1 , Ilenia Schillaci 1 , Sara Capra 1 , Sabrina Berti 1 , Simona Moscatiello 1 , Sara Flamigni 1 , Andrea Scozzarella 2 , Luca Bernardini 2 , Marcello Lanari 2 , Uberto Pagotto 1 & Guido Di Dalmazi 1
1Endocrinology and Diabetes Prevention and Care IRCCS Sant’Orsola, Bologna, Italy; 2Pediatric unit IRCCS Sant’Orsola, Bologna, Italy
JOINT3918
Background and Aim: Advanced hybrid closed-loop (AHCL) systems, MiniMed 780G (M) and Tandem Control-IQ (T), represent the most advanced technologies for glucose control in patients with Type 1 Diabetes (T1D). Limited comparison data are available in the literature yet. We aimed at identifying differences in glucose parameter between M and T in adult and pediatric patients.
Method: We retrospectively collected data of 199 patients with T1D: 93 adults (>18 years: 59M, 34T), 56 adolescents (12-18 yo; 16M, 40T) and 50 children (<12 yo; 9M, 41T). We analyzed AGP data before AHCL initiation and after 6 and 12 months. Target-Time-In-Range (TIR) was set at >70%.
Results: No differences in insulin/kg ratio were observed between M and T users, at 6 and 12 months, among age groups. Adults: At 6 months and 12 months, patients with M showed higher TIR (6 months: 74%[67-79] vs 66%[59-76], p=.021; 12 months: 73%[69-80] vs 66%[59-72], p=.002), lower Time Above Range (TAR) >250mg/dl (P < .001 for both times), Glucose Management Indicator (GMI, p=.005 for both times), and Coefficient of Variability (CV, p=.007 and p=.016 respectively) than T users. At 12 months, 61% of M users had a target-TIR vs 38% T (p=.049). Adolescents: At 6 and 12 months, patients using M vs T had higher TIR (6 months: 82%[75-87] vs 61%[53-69], P < .001; 12 months: 79%[69-85] vs 58%[47-68]; P < .001), and lower TAR>250mg/dl (P < .001 for both times), GMI (P < .001 and p=.005, respectively), and CV (P < .001 and p=.002, respectively). Time Below Range (TBR) at 12 months was higher in M vs T users (2%[1-3] vs 1%[0-2], p=.023). At 12 months, 69% of M users had a target-TIR vs 18% T (P < .001). Children: no significant differences were observed, but with a small cohort of M users.
Conclusion: With similar insulin/kg, M seems to be more effective in improving TIR, TAR, GMI and CV in adults and adolescents but T appears to be better in reducing TBR in adolescents at 12 mo.
Volume 110
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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